DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	572	Identity:	154/572 - (26%)
Similarity:	255/572 - (44%)	Gaps:	112/572 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WSPRVALLFLALALSQPDELVEAAGPLKVLGLFPHPG-VSHFHFFHPIMKGLAEAGHDVSVV--S 63
            ||.||.::                           || .||:|...|:::.|.:..|.|:|:  |
Zfish    19 WSGRVLVM---------------------------PGEYSHWHNMRPVIEALVDKNHSVTVLVGS 56

  Fly    64 HFPDKHPVAH-------YKDFPLTGMDK-------------LTNSVDLKF---FEKRTFYSHFQE 105
            ..|   .|.|       |..|.: .|:|             .||....|:   |......|.|.|
Zfish    57 SSP---TVPHTQKERFEYHVFKV-NMEKEEADAAMRDMIHLFTNDTAAKYEGEFVMWKVMSKFVE 117

  Fly   106 FFLLYDWGKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMG----VAHQLQAP-VIALSS 165
            |..:|..|       |....|.:.| |...:||:.     :|.||.    :|.:|..| ||::.:
Zfish   118 FGDVYFRG-------LFDVGLLKTL-RDSNYDVLF-----SDPMMPFSDLMAQKLNIPQVISMRA 169

  Fly   166 ---------CVMMPWHYERMGAPLIPSHIPALFMAQ--SQHMNFGGRLANW--FSTHALNWMYKL 217
                     |..||       ||  ||::||:.:..  :..|:|..|:.|.  :..|::  .:.|
Zfish   170 TFAYAAERLCGQMP-------AP--PSYVPAVALTDHLTDRMSFMERVENMLLYIVHSI--AFPL 223

  Fly   218 LSVPAADAMVQYKFGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPA 282
            ::....|.......|... ::.|.:....:..:..::....|:..|||...:||:|.:.:|||..
Zfish   224 VATFTFDGYYSEILGKPT-TMCETMGKVDICLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSK 287

  Fly   283 DLQRILDNA-EEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHI 346
            :|:..:.:: :.||::.|.||||:  :|::.:.:.|..|:.::.|||:|::..:|.....||..|
Zfish   288 ELEEFVQSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKI 350

  Fly   347 MKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFE 411
            ..|:||.|:|.||..|.|::|||..|..||.|.|||:|..|::|||..|...:..:|...:|:..
Zfish   351 YDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVVLDIH 415

  Fly   412 DIGENTVMRALKKALDK-KFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEM 475
            .:|...::.|||..::. .:.::...:|...|.:|.:.|..|::|:|.|....||..|:..|.|:
Zfish   416 TMGSKDLVDALKAVVNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHEL 480

  Fly   476 SRFVYYSLDVYAVLALVLGSIIASWV----WLLRLCCGSS----AAQKTKKD 519
            |.:.|:.|||.|.|..:...|...||    :|.|.|...:    ..||.||:
Zfish   481 SWYQYHCLDVAAFLLSITALITFLWVKACCFLFRRCVRKTRPERKRQKNKKE 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	135/506 (27%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	148/555 (27%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	74/237 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584372
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740