DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and UGT2B17

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001068.1	Gene:	UGT2B17 / 7367	HGNCID:	12547	Length:	530	Species:	Homo sapiens

Alignment Length:	522	Identity:	135/522 - (25%)
Similarity:	245/522 - (46%)	Gaps:	67/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SHFHFFHPIMKGLAEAGHDVSVVSH------------------FPDKHPVAHYKDFPLTGMDKLT 86
            ||:.....|::.|.:.||:|.|::.                  :|........:||.:...|:.|
Human    34 SHWINMKTILEELVQRGHEVIVLTSSASILVNASKSSAIKLEVYPTSLTKNDLEDFFMKMFDRWT 98

  Fly    87 NSVDLKFFEKRTFYSHFQEFFLLYDWGKQTCNLTLRSEAL--QQILRR--PGRFDVIIMEQFNTD 147
            .|:     .|.||:|:|.:...|. |.....|:.|..:|:  ::::|:  ..:|||::.:..| .
Human    99 YSI-----SKNTFWSYFSQLQELC-WEYSDYNIKLCEDAVLNKKLMRKLQESKFDVLLADAVN-P 156

  Fly   148 CMMGVAHQLQAPVIALSSCVMMPWHYERMGAPLI--PSHIPALFMAQSQHMNFGGRLAN------ 204
            |...:|..|..|.: .|....:.:..|:.|...:  ||::|.:....|..|.|..|:.|
Human   157 CGELLAELLNIPFL-YSLRFSVGYTVEKNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLY 220

  Fly   205 ---WFSTHAL-NWMYKLLSVPAADAMVQYKFGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPN 265
               ||..:.| .|          |.......|... ::.|.:....|:.:..::....|:...||
Human   221 FDFWFQAYDLKKW----------DQFYSEVLGRPT-TLFETMGKAEMWLIRTYWDFEFPRPFLPN 274

  Fly   266 VIELGGIHIQKSKPLPADLQRILDNA-EEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVI 329
            |..:||:|.:.:||||.:::..:.:: |.|:::.|.||||  :::|....:.|..|:|::.|||:
Human   275 VDFVGGLHCKPAKPLPKEMEEFVQSSGENGIVVFSLGSMI--SNMSEESANMIASALAQIPQKVL 337

  Fly   330 WKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFV 394
            |:::.:.......|..:.|||||.|:|.||..|.|::|||..|..||.|.|:|:|..|::.||..
Human   338 WRFDGKKPNTLGSNTRLYKWLPQNDLLGHPKTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHD 402

  Fly   395 NTAALVERGMGTILNFEDIGENTVMRALKKAL-DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEH 458
            |.|.:..:|....::...:....::.|||..: |..:.:....:|...|.:|.:.|..|::|:|.
Human   403 NIAHMKAKGAALSVDIRTMSSRDLLNALKSVINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEF 467

  Fly   459 VAHTGGAPLLKPSAVEMSRFVYYSLDVYAVLALVLGSIIASWVWLLRLCC------GSSAAQKTK 517
            |....||..|:.:|..::...|:||||.|.|.    :.:|:.::::..||      .:...:|.|
Human   468 VMRHKGAKHLRVAAHNLTWIQYHSLDVIAFLL----ACVATMIFMITKCCLFCFRKLAKTGKKKK 528

  Fly   518 KD 519
            :|
Human   529 RD 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	123/477 (26%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	132/508 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150100
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740