DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and UGT2B7

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001065.2	Gene:	UGT2B7 / 7364	HGNCID:	12554	Length:	529	Species:	Homo sapiens

Alignment Length:	557	Identity:	141/557 - (25%)
Similarity:	263/557 - (47%)	Gaps:	71/557 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WSPRVALLFLALALSQPD---ELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVS 63
            |:..:.|:.|:...|..:   .||.||            ..||:.....|:..|.:.||:|:|::
Human     5 WTSVILLIQLSFCFSSGNCGKVLVWAA------------EYSHWMNIKTILDELIQRGHEVTVLA 57

  Fly    64 HF------PDKHPVAHYKDFPLTGMDK--LTNSV--------DLKFFEKRTFYSHF---QEFFLL 109
            ..      |:.......:.:| |.:.|  |.|.:        ||   .|.||:.:|   ||...:
Human    58 SSASILFDPNNSSALKIEIYP-TSLTKTELENFIMQQIKRWSDL---PKDTFWLYFSQVQEIMSI 118

  Fly   110 Y-DWGKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAP-VIALSSCVMMP-W 171
            : |..::.|...:.::...:.::. .|||||..:.. ..|...:|.....| |.:||   ..| :
Human   119 FGDITRKFCKDVVSNKKFMKKVQE-SRFDVIFADAI-FPCSELLAELFNIPFVYSLS---FSPGY 178

  Fly   172 HYERMGAPLI--PSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFGHD 234
            .:|:.....|  ||::|.:....:..|.|..|:.|.......::.:::..:...|.......|..
Human   179 TFEKHSGGFIFPPSYVPVVMSELTDQMTFMERVKNMIYVLYFDFWFEIFDMKKWDQFYSEVLGRP 243

  Fly   235 VPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNA-EEGVILI 298
            . ::.|.:....::.:...::...|....|||..:||:|.:.:||||.:::..:.:: |.||::.
Human   244 T-TLSETMGKADVWLIRNSWNFQFPYPLLPNVDFVGGLHCKPAKPLPKEMEDFVQSSGENGVVVF 307

  Fly   299 SWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPP----NMHIMKWLPQRDILCHP 359
            |.|||:  ::::..:.:.|..|:|::.|||:|:::.    |:|.    |..:.||:||.|:|.||
Human   308 SLGSMV--SNMTEERANVIASALAQIPQKVLWRFDG----NKPDTLGLNTRLYKWIPQNDLLGHP 366

  Fly   360 NVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKK 424
            ..:.|::|||..|..||.|.|:|:|..|::.||..|.|.:..||....::|..:....::.|||:
Human   367 KTRAFITHGGANGIYEAIYHGIPMVGIPLFADQPDNIAHMKARGAAVRVDFNTMSSTDLLNALKR 431

  Fly   425 AL-DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAV 488
            .: |..:.:....:|...|.:|.:.|..|::|:|.|....||..|:.:|.:::.|.|:||||...
Human   432 VINDPSYKENVMKLSRIQHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSLDVIGF 496

  Fly   489 LALVLGSIIASWVWLLRLCC------GSSAAQKTKKD 519
            |.:.:.::|    :::..||      .:..|:|.|.|
Human   497 LLVCVATVI----FIVTKCCLFCFWKFARKAKKGKND 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	125/490 (26%)
UGT2B7	NP_001065.2	UDPGT	24..525	CDD:278624	134/532 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150128
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740