DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and UGT2A2

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001099147.2	Gene:	UGT2A2 / 574537	HGNCID:	28183	Length:	536	Species:	Homo sapiens

Alignment Length:	545	Identity:	142/545 - (26%)
Similarity:	263/545 - (48%)	Gaps:	81/545 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSV--------V 62
            |.:|...|.|:   |:|.:...|    ::|..| ||:.....|::.|.:..|:|:|        :
Human    14 VQMLVFNLTLT---EVVLSGNVL----IWPTDG-SHWLNIKIILEELIQRNHNVTVLASSATLFI 70

  Fly    63 SHFPDKH------PVAHYKDFPLTGMDKLTNSVDLKFFEKR----TFYSHFQEFFLLYDW----G 113
            :..||..      ||::.|    :.:|.|...:.:.:.:.|    |.::.::|...|.|.    .
Human    71 NSNPDSPVNFEVIPVSYKK----SNIDSLIEHMIMLWIDHRPTPLTIWAFYKELGKLLDTFFQIN 131

  Fly   114 KQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAP---VIALSSCVMMPWHYER 175
            .|.|:..|::..|...|:: |.|||::.:.. |.|...||.:|..|   .:..|....:..|..:
Human   132 IQLCDGVLKNPKLMARLQK-GGFDVLVADPV-TICGDLVALKLGIPFMYTLRFSPASTVERHCGK 194

  Fly   176 MGAPLIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMY------------KLLSVPAADAMVQ 228
            :.||:  |::||.....:..|.||.|:.|..|....::::            |:|..|.
Human   195 IPAPV--SYVPAALSELTDQMTFGERIKNTISYSLQDYIFQSYWGEWNSYYSKILGRPT------ 251

  Fly   229 YKFGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNA-E 292
                    ::.|.:....::.:..::....|:...||...:||:|.:.:||||.:::..:.:: :
Human   252 --------TLCETMGKAEIWLIRTYWDFEFPRPYLPNFEFVGGLHCKPAKPLPKEMEEFIQSSGK 308

  Fly   293 EGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENE---TLPNQPPNMHIMKWLPQRD 354
            .||::.|.|||::  :|:..|.:.|..|:|::.|||:|:::.:   ||.|   |..:..|:||.|
Human   309 NGVVVFSLGSMVK--NLTEEKANLIASALAQIPQKVLWRYKGKKPATLGN---NTQLFDWIPQND 368

  Fly   355 ILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVM 419
            :|.||..|.|::|||..|..||.|.|||:|..||:.||..|.|.:..:|....:|...:....::
Human   369 LLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMFADQPDNIAHMKAKGAAVEVNLNTMTSVDLL 433

  Fly   420 RALKKALDK-KFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSL 483
            .||:..::: .:.:.|..:|...|.:|.:.|..|::|:|.|....||..|:.:|.:::.|.|:||
Human   434 SALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLTWFQYHSL 498

  Fly   484 DVYAVLALVLGSIIASWVWLLRLCC 508
            ||...|.:    .:.:.::|:..||
Human   499 DVIGFLLV----CVTTAIFLVIQCC 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	129/502 (26%)
UGT2A2	NP_001099147.2	UDPGT	30..524	CDD:278624	136/526 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150088
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.740