DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	522	Identity:	141/522 - (27%)
Similarity:	235/522 - (45%)	Gaps:	60/522 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVS-----HFPDK-------HPVAHYKD-FPLT 80
            ||| :||..| ||:.....:::.|...||...|::     |..::       :||.:.:. |...
  Rat    27 KVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTLQTYPVPYTRQGFRQQ 89

  Fly    81 GMDKL-----TNSVDLKFFEKRTFYSHFQEFFLLYDWGKQTCNLTLRSEALQQILRRPGRFDVII 140
            .|..:     |.:....|.|......:.....|      ::|...|.:.:|.|.| ....||:::
  Rat    90 MMRNIKVVFETGNYVKTFLETSEILKNISTVLL------RSCMNLLHNGSLLQHL-NSSSFDMVL 147

  Fly   141 MEQFNTD----CMMGVAHQLQAPVIALSSCVMMPWHYERMGAPLIPSHIPALFMAQSQHMNFGGR 201
                 ||    |...:|..|..|.:.....:......|....|...|:||.|....|.||.|..|
  Rat   148 -----TDPVIPCGAVLAKYLGIPTVFFLRYIPCGIDSEATQCPKPSSYIPNLLTMLSDHMTFLQR 207

  Fly   202 LANWFSTHALNWM-------YKLLSVPAADAMVQYKFGHDVPSVGELVKNTSMFFVNQHYSLSGP 259
            :.|.....||.::       |:.|    |..::|.:.     |:.|::.:.|::.....:....|
  Rat   208 VKNMLYPLALKYICHFSFTRYESL----ASELLQREV-----SLVEVLSHASVWLFRGDFVFDYP 263

  Fly   260 KVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVILISWGSMIRANSLSAAKRDGIIRAVAR 323
            :...||::.:|||:....|||..:.:..:: :.|.|:::.|.|||:  :.:...|...|..|:.|
  Rat   264 RPVMPNMVFIGGINCVIKKPLSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGR 326

  Fly   324 LKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPM 388
            :.|.|:|::......|...|..::|||||.|:|.||..:.|::|.|..|..|....|||:|..|:
  Rat   327 IPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPL 391

  Fly   389 YGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKALDKKFHDAAKVVSHSFH-HRPQQALHTA 452
            :|||..|...:..||.|..||..::..:.:..|||..::.|.:....:...|.| .||.:.|..|
  Rat   392 FGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLA 456

  Fly   453 IWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGSII---ASWVWLLRLCCGSSAA 513
            ::|||:|....|||.|:|:|.:::.:.|:||||.. :||:||..:.   .|..:..|.|.|....
  Rat   457 VFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGR 521

  Fly   514 QK 515
            .|
  Rat   522 VK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	128/483 (27%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	140/519 (27%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	81/247 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343982
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740