DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and ugt1b1

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170917.1	Gene:	ugt1b1 / 558508	ZFINID:	ZDB-GENE-080227-10	Length:	528	Species:	Danio rerio

Alignment Length:	555	Identity:	158/555 - (28%)
Similarity:	258/555 - (46%)	Gaps:	69/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSPRVALLFLALALSQPDELVEAAGPLKVLG----LFPHPGVSHFHFFHPIMKGLAEAGHDVSV 61
            :|.....||.|.|          :||...|.|    :.|..| ||:.....:...||..||||.|
Zfish     7 LWGLGSGLLLLWL----------SAGLRPVQGGRVLVMPVEG-SHWLSMKVLATELARRGHDVLV 60

  Fly    62 VSHFPDKHPVAHYKD------FPLTGMDKLTNSVDLKFFEKRTFYSH--FQEFF-----LLYDWG 113
            :  .|:|:.:....:      ||:. :.|...|..||.|::..|...  ..:.|     ||...|
Zfish    61 L--VPEKNILIQSSELFRTETFPVK-ISKEQLSKSLKGFQQGVFTRSPALMDVFVQLERLLNFTG 122

  Fly   114 KQT--CNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERM 176
            .|.  |...|.:|.|.:.|:.. .|::::.:.| ..|...:|..|..|.:....  .||...:.:
Zfish   123 SQVEGCESLLYNEPLMRKLKEQ-NFELMLTDPF-LPCGPIIATALGVPAVYFLR--GMPCGIDLL 183

  Fly   177 GA--PLIPSHIPALFMAQSQHMNFGGRLANWFSTH----ALNWMYKLLSVPAADAM---VQYKFG 232
            .:  |..||::|......|..|||..|:.|:|.:.    ....||......||..:   |.||
Zfish   184 ASQCPSPPSYVPRFHSGTSDKMNFVERIRNFFMSGFELVLCKVMYASFDELAARYLKKDVTYK-- 246

  Fly   233 HDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVI 296
                   |::...:::.....::...|:...||::.:|||:.|||..:.|:::..:: :.|.|::
Zfish   247 -------EIIGRGALWLHRYDFTFEYPRPIMPNMVFIGGINCQKSAEISAEVEEFVNGSGEHGIV 304

  Fly   297 LISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNV 361
            :.|.||::  :|:...|.|...:|.:.:.|:|:|::..|...|.|.|:.:||||||.|:|.||..
Zfish   305 VFSLGSLV--SSMPKEKADIFFKAFSMIPQRVLWRYTGEIPDNVPENVKLMKWLPQNDLLGHPKA 367

  Fly   362 KVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL 426
            :.|::|||..|..|....|||:|..|::|||..|...:..||:|.||:..||...|::.||...:
Zfish   368 RAFITHGGTHGIYEGICRGVPMVMLPLFGDQADNVHRVATRGVGVILSIHDITVETLLDALNSVI 432

  Fly   427 -DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAVLA 490
             :..:....:.:|...:.||.|.|..|::|.|.|....||..|:|:|.|::...|:||||...:.
Zfish   433 NNSSYKQKMQKLSAIHNDRPIQPLDLAVFWTEFVMRHKGADHLRPAAHELNWLQYHSLDVIGFML 497

  Fly   491 LVLGSI------IASWVWLLRLCCGSSAAQKTKKD 519
            |::..:      ..|..|  |.||..:  ||.|:|
Zfish   498 LIVLIVTLAMLKCCSLCW--RRCCRKT--QKRKED 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	139/490 (28%)
ugt1b1	NP_001170917.1	UDPGT	29..524	CDD:278624	145/517 (28%)
ugt1b1	NP_001170917.1	egt	<267..507	CDD:223071	81/241 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584321
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930