DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and UGT1A3

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_061966.1	Gene:	UGT1A3 / 54659	HGNCID:	12535	Length:	534	Species:	Homo sapiens

Alignment Length:	543	Identity:	152/543 - (27%)
Similarity:	252/543 - (46%)	Gaps:	49/543 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDK 68
            |.:|...|.|...||  ..|:.   ||| :.|..| ||:.....:::.|...||...|::  |:.
Human    10 PWLATGLLLLLSVQP--WAESG---KVL-VVPIDG-SHWLSMREVLRELHARGHQAVVLT--PEV 65

  Fly    69 HPVAHYKD---FPLT------GMDKLTNSV---DLKFFEKRTFYSHF-------QEFFLLYDWGK 114
            :  .|.|:   |.||      ..|:....|   ...:||...|...|       ....|:|   .
Human    66 N--MHIKEENFFTLTTYAISWTQDEFDRHVLGHTQLYFETEHFLKKFFRSMAMLNNMSLVY---H 125

  Fly   115 QTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGAP 179
            ::|...|.:|||.:.|.... |||::.:..|. |...:|..|..|.:.....:.....::....|
Human   126 RSCVELLHNEALIRHLNATS-FDVVLTDPVNL-CAAVLAKYLSIPTVFFLRNIPCDLDFKGTQCP 188

  Fly   180 LIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFGHDVPSVGELVKN 244
            ...|:||.|....|.||.|..|:.|.....||:::....|.|.| ::....|..:| ||.:::.:
Human   189 NPSSYIPRLLTTNSDHMTFMQRVKNMLYPLALSYICHAFSAPYA-SLASELFQREV-SVVDILSH 251

  Fly   245 TSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVILISWGSMIRANS 308
            .|::.....:.:..|:...||::.:|||:....|||..:.:..:: :.|.|:::.|.|||:  :.
Human   252 ASVWLFRGDFVMDYPRPIMPNMVFIGGINCANRKPLSQEFEAYINASGEHGIVVFSLGSMV--SE 314

  Fly   309 LSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGT 373
            :...|...|..|:.::.|.|:|::......|...|..::|||||.|:|.||..:.|::|.|..|.
Human   315 IPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGV 379

  Fly   374 SEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL-DKKFHDAAKVV 437
            .|:...|||:|..|::|||..|...:..:|.|..||..::....:..|||..: ||.:.:....:
Human   380 YESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRL 444

  Fly   438 SHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGSIIASW- 500
            |.....||.:.|..|::|||.|....|||.|:|:|.:::.:.|:||||.. :||:||.....::
Human   445 SSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFK 509

  Fly   501 --VWLLRLCCGSSA----AQKTK 517
              .:..|.|.|...    |.|:|
Human   510 CCAYGYRKCLGKKGRVKKAHKSK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	132/481 (27%)
UGT1A3	NP_061966.1	UDPGT	29..525	CDD:278624	142/513 (28%)
UGT1A3	NP_061966.1	egt	<262..508	CDD:223071	79/247 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150154
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840