DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and UGT1A4

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_009051.1	Gene:	UGT1A4 / 54657	HGNCID:	12536	Length:	534	Species:	Homo sapiens

Alignment Length:	537	Identity:	150/537 - (27%)
Similarity:	246/537 - (45%)	Gaps:	37/537 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDK 68
            ||:|...|.|...||  ..|:.   ||| :.|..| |.:......::.|...||...|::...:.
Human    10 PRLATGLLLLLSVQP--WAESG---KVL-VVPTDG-SPWLSMREALRELHARGHQAVVLTPEVNM 67

  Fly    69 HPVAHYKDFPLTG---------MDKLTNSVDLKFFEKRTFYSHFQEFFLLYDWGK----QTCNLT 120
            | :...|.|.||.         .|::|......|||.......:.....:.:...    :.|...
Human    68 H-IKEEKFFTLTAYAVPWTQKEFDRVTLGYTQGFFETEHLLKRYSRSMAIMNNVSLALHRCCVEL 131

  Fly   121 LRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGAPLIPSHI 185
            |.:|||.:.|.... |||::.:..|. |...:|..|..|.:.....:.....::....|...|:|
Human   132 LHNEALIRHLNATS-FDVVLTDPVNL-CGAVLAKYLSIPAVFFWRYIPCDLDFKGTQCPNPSSYI 194

  Fly   186 PALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFGHDVPSVGELVKNTSMFFV 250
            |.|....|.||.|..|:.|.....||:::....|.|.| ::....|..:| ||.:||...|::..
Human   195 PKLLTTNSDHMTFLQRVKNMLYPLALSYICHTFSAPYA-SLASELFQREV-SVVDLVSYASVWLF 257

  Fly   251 NQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVILISWGSMIRANSLSAAKR 314
            ...:.:..|:...||::.:|||:....|||..:.:..:: :.|.|:::.|.|||:  :.:...|.
Human   258 RGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEIPEKKA 320

  Fly   315 DGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYC 379
            ..|..|:.::.|.|:|::......|...|..::|||||.|:|.||..:.|::|.|..|..|:...
Human   321 MAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICN 385

  Fly   380 GVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL-DKKFHDAAKVVSHSFHH 443
            |||:|..|::|||..|...:..:|.|..||..::....:..|||..: ||.:.:....:|.....
Human   386 GVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKD 450

  Fly   444 RPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGSIIASW---VWLL 504
            ||.:.|..|::|||.|....|||.|:|:|.:::.:.|:||||.. :||:||.....::   .:..
Human   451 RPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGY 515

  Fly   505 RLCCGSSA----AQKTK 517
            |.|.|...    |.|:|
Human   516 RKCLGKKGRVKKAHKSK 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	129/475 (27%)
UGT1A4	NP_009051.1	UDPGT	29..525	CDD:278624	139/507 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150153
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740