Protein Alignment Ugt36D1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_001246082.2
• Gene: Ugt36D1 / 35138
• FlyBaseID: FBgn0032713
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 542
• Identity: 153/542 - (28%)
• Similarity: 254/542 - (46%)
• Gaps: 47/542 - (8%)

  Fly     4 PRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDK 68
            |::|...|.|...||  ..|:.   ||| :.|..| ||:......::.|...||.|.|::...:.
Human    10 PQLATGLLLLLSVQP--WAESG---KVL-VVPTDG-SHWLSMREALRDLHARGHQVVVLTLEVNM 67

  Fly    69 HPVAHYKDFPLTGMDKLTNSVDLKFFE-KRTFYSHFQEFF----LLYDWGK-------------Q 115
            : :.....|.||     |.::.....| .|....|.|.||    ||..:.:             :
Human    68 Y-IKEENFFTLT-----TYAISWTQDEFDRLLLGHTQSFFETEHLLMKFSRRMAIMNNMSLIIHR 126

  Fly   116 TCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGAPL 180
            :|...|.:|||.:.|.... |||::.:.|:. |...:|..|..|.:.....:.....::....|.
Human   127 SCVELLHNEALIRHLHATS-FDVVLTDPFHL-CAAVLAKYLSIPAVFFLRNIPCDLDFKGTQCPN 189

  Fly   181 IPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFGHDVPSVGELVKNT 245
            ..|:||.|....|.||.|..|:.|.....||:::...:|.|.| ::....|..:| ||.:||.:.
Human   190 PSSYIPRLLTTNSDHMTFLQRVKNMLYPLALSYLCHAVSAPYA-SLASELFQREV-SVVDLVSHA 252

  Fly   246 SMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVILISWGSMIRANSL 309
            |::.....:.:..|:...||::.:|||:....|||..:.:..:: :.|.|:::.|.|||:  :.:
Human   253 SVWLFRGDFVMDYPRPIMPNMVFIGGINCANGKPLSQEFEAYINASGEHGIVVFSLGSMV--SEI 315

  Fly   310 SAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTS 374
            ...|...|..|:.::.|.|:|::......|...|..::|||||.|:|.||..:.|::|.|..|..
Human   316 PEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVY 380

  Fly   375 EAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL-DKKFHDAAKVVS 438
            |:...|||:|..|::|||..|...:..:|.|..||..::....:..|||..: ||.:.:....:|
Human   381 ESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLS 445

  Fly   439 HSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGSIIASW-- 500
            .....||.:.|..|::|||.|....|||.|:|:|.:::.:.|:||||.. :||:||.....::
Human   446 SLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKC 510

  Fly   501 -VWLLRLCCGSSA----AQKTK 517
             .:..|.|.|...    |.|:|
Human   511 CAYGYRKCLGKKGRVKKAHKSK 532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	133/480 (28%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	143/512 (28%)
		egt	<262..508	CDD:223071	79/247 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150152
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840