Protein Alignment Ugt36D1 and UGT1A6

DIOPT Version :9

• Sequence 1: NP_001246082.2
• Gene: Ugt36D1 / 35138
• FlyBaseID: FBgn0032713
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_001063.2
• Gene: UGT1A6 / 54578
• HGNCID: 12538
• Length: 532
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 149/566 - (26%)
• Similarity: 254/566 - (44%)
• Gaps: 106/566 - (18%)

  Fly     8 LLFLAL-ALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVV--------- 62
            :.|||| .:...|:|:          :.|..| ||:.....|::.|::.||::.||
Human    15 VFFLALWGMVVGDKLL----------VVPQDG-SHWLSMKDIVEVLSDRGHEIVVVVPEVNLLLK 68

  Fly    63 --SHFPDK-HPVAHYKDFPLTGMDKLTN---SVDLKFFEKRTFYSHFQEFF-------------- 107
              .::..| :||.:       ..::|.|   |.....|.:|:|.:..|..:
Human    69 ESKYYTRKIYPVPY-------DQEELKNRYQSFGNNHFAERSFLTAPQTEYRNNMIVIGLYFINC 126

  Fly   108 --LLYDWGKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTD----CMMGVAHQLQAPVIAL--- 163
              ||.|  :.|.|....|           :||.:.     ||    |.:.:|..|..|.:.|
Human   127 QSLLQD--RDTLNFFKES-----------KFDALF-----TDPALPCGVILAEYLGLPSVYLFRG 173

  Fly   164 SSCVMMPWHYERMGAPLIPSHIPALFMAQSQHMNFGGRLANW-------FSTHALNWMYKLLSVP 221
            ..| .:...:.|...|:  |:||..:...|.||.|..|:||:       :..:.|...|:.|
Human   174 FPC-SLEHTFSRSPDPV--SYIPRCYTKFSDHMTFSQRVANFLVNLLEPYLFYCLFSKYEEL--- 232

  Fly   222 AADAMVQYKFGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQR 286
             |.|:::    .||..: .|.:..|::.:...:.|..|:...||::.:|||:.:|.|.|..:.:.
Human   233 -ASAVLK----RDVDII-TLYQKVSVWLLRYDFVLEYPRPVMPNMVFIGGINCKKRKDLSQEFEA 291

  Fly   287 ILD-NAEEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWL 350
            .:: :.|.|:::.|.|||:  :.:...|...|..|:.::.|.|:|::......|...|..::|||
Human   292 YINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWL 354

  Fly   351 PQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGE 415
            ||.|:|.||..:.|::|.|..|..|:...|||:|..|::|||..|...:..:|.|..||..::..
Human   355 PQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTS 419

  Fly   416 NTVMRALKKAL-DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFV 479
            ..:..|||..: ||.:.:....:|.....||.:.|..|::|||.|....|||.|:|:|.:::.:.
Human   420 EDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQ 484

  Fly   480 YYSLDVYA-VLALVLGSIIASW---VWLLRLCCGSSA----AQKTK 517
            |:||||.. :||:||.....::   .:..|.|.|...    |.|:|
Human   485 YHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSK 530

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	130/507 (26%)
UGT1A6	NP_001063.2	egt	15..506	CDD:223071	143/540 (26%)
		UDPGT	27..523	CDD:278624	142/545 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740