Protein Alignment Ugt36D1 and UGT1A7

DIOPT Version :9

• Sequence 1: NP_001246082.2
• Gene: Ugt36D1 / 35138
• FlyBaseID: FBgn0032713
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 549
• Identity: 144/549 - (26%)
• Similarity: 241/549 - (43%)
• Gaps: 101/549 - (18%)

  Fly    25 AGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPD-------------KHPVAHY-- 74
            ||.|.|:   |..| ||:.....:::.|...||:|.||  .|:             |.....|
Human    25 AGKLLVV---PMDG-SHWFTMQSVVEKLILRGHEVVVV--MPEVSWQLGRSLNCTVKTYSTSYTL 83

  Fly    75 ----KDF----------PLTGMDKLTNSVDLKFFEKRTFYSHFQEFF---LLYDWGKQTCNLTLR 122
                ::|          ||.....|..|.....|:  .|:|:.:..|   .|.::.|::|
Human    84 EDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFD--LFFSNCRSLFNDRKLVEYLKESC----- 141

  Fly   123 SEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGA--PLIPSHI 185
                         ||.:.::.|:. |.:.||.....|.:..:..:..  ||...||  |...|::
Human   142 -------------FDAVFLDPFDA-CGLIVAKYFSLPSVVFARGIFC--HYLEEGAQCPAPLSYV 190

  Fly   186 PALFMAQSQHMNFGGRLAN------------WFSTHALNWMYKLLSVPAADAMVQYKFGHDVPSV 238
            |.|.:..|..|.|..|:.|            :|..:.|....::|..|.              :.
Human   191 PRLLLGFSDAMTFKERVWNHIMHLEEHLFCPYFFKNVLEIASEILQTPV--------------TA 241

  Fly   239 GELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVILISWGS 302
            .:|..:||::.:...:.|..||...||:|.:|||:..:.||:|.:.:..:: :.|.|:::.|.||
Human   242 YDLYSHTSIWLLRTDFVLEYPKPVMPNMIFIGGINCHQGKPVPMEFEAYINASGEHGIVVFSLGS 306

  Fly   303 MIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSH 367
            |:  :.:...|...|..|:.::.|.|:|::......|...|..::|||||.|:|.||..:.|::|
Human   307 MV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITH 369

  Fly   368 GGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL-DKKFH 431
            .|..|..|:...|||:|..|::|||..|...:..:|.|..||..::....:..|||..: ||.:.
Human   370 AGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYK 434

  Fly   432 DAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGS 495
            :....:|.....||.:.|..|::|||.|....|||.|:|:|.:::.:.|:||||.. :||:||..
Human   435 ENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTV 499

  Fly   496 IIASW---VWLLRLCCGSSA----AQKTK 517
            ...::   .:..|.|.|...    |.|:|
Human   500 AFITFKCCAYGYRKCLGKKGRVKKAHKSK 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	130/504 (26%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	140/539 (26%)
		egt	<264..504	CDD:223071	79/241 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150114
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740