DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and UGT1A8

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_061949.3	Gene:	UGT1A8 / 54576	HGNCID:	12540	Length:	530	Species:	Homo sapiens

Alignment Length:	562	Identity:	151/562 - (26%)
Similarity:	254/562 - (45%)	Gaps:	85/562 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WSPRVAL---LFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVS 63
            |:..:.|   |.|....::       ||.|.|:   |..| ||:.....:::.|...||:|.||
Human     6 WTSPIPLCVSLLLTCGFAE-------AGKLLVV---PMDG-SHWFTMQSVVEKLILRGHEVVVV- 58

  Fly    64 HFPD---------KHPVAHYK-DFPLTGMDK-LTNSVDLKF-FEKRTFYSHF----QEFFLLYDW 112
             .|:         ...|..|. .:.|..:|: ..:..|.:: .:.|:.:|.|    ..||.|:
Human    59 -MPEVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF-- 120

  Fly   113 GKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALS---SCVMMPWHYE 174
             ...|........|.:.|:. ..||.:.::.|:. |.:.||.....|.:..:   :|     ||.
Human   121 -FSHCRSLFNDRKLVEYLKE-SSFDAVFLDPFDA-CGLIVAKYFSLPSVVFARGIAC-----HYL 177

  Fly   175 RMGA--PLIPSHIPALFMAQSQHMNFGGRLAN------------WFSTHALNWMYKLLSVPAADA 225
            ..||  |...|::|.:.:..|..|.|..|:.|            :||.:||....::|..|.
Human   178 EEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPV--- 239

  Fly   226 MVQYKFGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD- 289
                       :..:|..:||::.:...:.|..||...||:|.:|||:..:.||||.:.:..::
Human   240 -----------TAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINA 293

  Fly   290 NAEEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRD 354
            :.|.|:::.|.|||:  :.:...|...|..|:.::.|.|:|::......|...|..::|||||.|
Human   294 SGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQND 356

  Fly   355 ILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVM 419
            :|.||..:.|::|.|..|..|:...|||:|..|::|||..|...:..:|.|..||..::....:.
Human   357 LLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLE 421

  Fly   420 RALKKAL-DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSL 483
            .|||..: ||.:.:....:|.....||.:.|..|::|||.|....|||.|:|:|.:::.:.|:||
Human   422 NALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSL 486

  Fly   484 DVYA-VLALVLGSIIASW---VWLLRLCCGSSA----AQKTK 517
            ||.. :||:||.....::   .:..|.|.|...    |.|:|
Human   487 DVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	133/495 (27%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	143/526 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150112
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740