DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	519	Identity:	145/519 - (27%)
Similarity:	251/519 - (48%)	Gaps:	54/519 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVS-----HFPDK-------HPVAHYKD---FP 78
            ||| :||..| ||:.....:::.|...||...|::     |..::       :||.:.|:   ..
  Rat    27 KVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTLQTYPVPYTKEEYRHH 89

  Fly    79 LTGMDKLTNSVDLKF-----FEKRTFYSHFQEFFLLYDWGKQTCNLTLRSEALQQILRRPGRFDV 138
            |.|  .|.|..:.:|     .::....::...|::      ::|...|.:.||.|.| ....|||
  Rat    90 LLG--HLQNFFETEFSLKLVLQRMAAVNNVSTFYV------RSCRGLLHNTALIQSL-NSSSFDV 145

  Fly   139 IIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGAPLIPSHIPALFMAQSQHMNFGGRLA 203
            ::.:.| ..|...:|..|:.|.:.....::....:|...:|...|:||.|....|.||:|..|:.
  Rat   146 VLTDPF-FPCGAVLAMYLRVPAVFFLQSMLCELEFEATNSPNPSSYIPRLLTLNSDHMSFLDRVK 209

  Fly   204 NWFSTHALNWMYKL------LSVPAADAMVQYKFGHDVPSVGELVKNTSMFFVNQHYSLSGPKVT 262
            |..  :.:.|||..      |:..|:|.:.:     :| ||.|::::.|::.:.:.:....|:..
  Rat   210 NML--YPVPWMYLCHVNYGSLARLASDLLQR-----EV-SVVEILRHASVWLLRKDFVFYYPRPF 266

  Fly   263 PPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQ 326
            .||::.:|||:....|||..:.:..:: :.|.|:::.|.|||:  :.:...|...|..|:.|:.|
  Rat   267 MPNMVFIGGINCANRKPLSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQ 329

  Fly   327 KVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGD 391
            .|:|::......|...|..::|||||.|:|.||..:.|::|.|..|..|....|||:|..|::||
  Rat   330 TVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGD 394

  Fly   392 QFVNTAALVERGMGTILNFEDIGENTVMRALKKALDKKFHDAAKVVSHSFH-HRPQQALHTAIWW 455
            |..|...:..||.|..||..::..:.:..|||..::.|.:....:...|.| .||.:.|..|::|
  Rat   395 QMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFW 459

  Fly   456 VEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGSII---ASWVWLLRLCCGSSAAQK 515
            ||:|....|||.|:|:|.:::.:.|:||||.. :||:||..:.   .|..:..|.|.|.....|
  Rat   460 VEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	132/480 (28%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	144/516 (28%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	89/284 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810