DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36D1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	571	Identity:	152/571 - (26%)
Similarity:	245/571 - (42%)	Gaps:	110/571 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSV------- 61
            |....|.||..|:|       ||.|.|:   |..| ||:.....:::.|...||:|.|
Mouse    11 PLCVCLLLASGLAQ-------AGRLLVV---PMDG-SHWFTMQTVVEKLLHKGHEVVVVVPEVSW 64

  Fly    62 --------------VSH-----------FPDKHPVAHYKDFPLTGMDKLTNSVDLKFFEKRTFYS 101
                          |||           |.|    |.:|.....|:..|.:|....|||  ..:|
Mouse    65 QLTKPLNFVVKTYAVSHTQEDLNREFKIFID----AQWKSQQEGGILPLLDSPAKGFFE--LLFS 123

  Fly   102 HFQEFF---LLYDWGKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIAL 163
            |.:..|   .|.::.|||                  .||.:.::.|:. |.:.||.....|.:..
Mouse   124 HCRSLFNDKKLVEYLKQT------------------SFDAVFLDPFDV-CGLTVAKYFSLPSVVF 169

  Fly   164 SSCVMMPWHYERMGAPLIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQ 228
            |..:...:..:....|..||:||.:.:..:..|.|..|..|            ||:.....|...
Mouse   170 SRGIFCHYLEDAAQCPSPPSYIPRMLLKFTDTMTFKERTRN------------LLAYMGERAFCH 222

  Fly   229 --YKFGHDVPS--------VGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPAD 283
              :|...|:.|        :.:|....|::.:...:.|..|:...||||.:|||:..:.|||..:
Mouse   223 KFFKSAADIASEVLQTPVTMTDLFSPVSIWLLRTDFVLEFPRPVMPNVIYIGGINCHQGKPLSKE 287

  Fly   284 LQRILD-NAEEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIM 347
            .:..:: :.|.|:::.|.|||:  :.:...|...|..|:.|:.|.|:|::......|...|..::
Mouse   288 FEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILV 350

  Fly   348 KWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFED 412
            |||||.|:|.||..:.|::|.|..|..|....|||:|..|::|||..|...:..||.|..||..:
Mouse   351 KWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLE 415

  Fly   413 IGENTVMRALKKALDKKFHDAAKVVSHSFH-HRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMS 476
            :..:.:..|||..::.|.:....:...|.| .||.:.|..|::|||:|....|||.|:|:|.:::
Mouse   416 MTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLT 480

  Fly   477 RFVYYSLDVYAVLALVLGSIIASWVWLLRLCC---------GSSAAQKTKK 518
            .:.|:||||...|.    :|:.:.|:::..||         |....:|:.|
Mouse   481 WYQYHSLDVIGFLL----AIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	134/507 (26%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	143/542 (26%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	88/283 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840180
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740