DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt1a10

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_964003.2	Gene:	Ugt1a10 / 394430	MGIID:	3580642	Length:	530	Species:	Mus musculus

Alignment Length:	572	Identity:	149/572 - (26%)
Similarity:	250/572 - (43%)	Gaps:	113/572 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPD- 67
            |....|.||..|.|       ||.|.|:   |..| ||:.....:::.|.:.||:|.||  .|:
Mouse    11 PLCVCLLLASGLVQ-------AGRLLVV---PMDG-SHWFDMQMVVEKLIQRGHEVVVV--IPEV 62

  Fly    68 -------------KHPVAH--------YKDFPLTGMDKLTNSV-------DLKFFEKRTFYSHFQ 104
                         .:.|:|        :|.|..|.......|:       ...|||  ..:||.:
Mouse    63 SWRLGKSLNCTVKTYSVSHTLEDLDREFKYFTYTQWKTPEQSIRSFMTGSARGFFE--LMFSHSR 125

  Fly   105 EFFLLYDWGKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVI---ALSSC 166
            ..|              ..:.|.:.|::.. ||.:.::.|:. |.:.||..|..|.:   .||.|
Mouse   126 GLF--------------NDKKLVEYLKQRS-FDAVFLDPFDV-CGLIVAKYLSLPSVIFARLSFC 174

  Fly   167 VMMPWHYERMGA--PLIPSHIPALFMAQSQHMNFGGRLAN------------WFSTHALNWMYKL 217
                 :|...||  |.:.|::|.||...:..|.|..|:.|            :|...|:....::
Mouse   175 -----YYLEEGAQCPSLLSYVPRLFSKYTDTMTFKERVWNHYMYIEDYVFCPYFFKTAVEIASEV 234

  Fly   218 LSVPAADAMVQYKFGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPA 282
            |..|.              ::.:|....|::.:...:.|..|:...||::.:||::..:.|||..
Mouse   235 LQTPV--------------TMTDLFSPVSIWLLRTDFVLEFPRPVMPNMVFVGGMNCLQGKPLSK 285

  Fly   283 DLQRILD-NAEEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHI 346
            :.:..:: :.|.|:::.|.|||:  :.:...|...|..|:.|:.|.|:|::......|...|..:
Mouse   286 EFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTIL 348

  Fly   347 MKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFE 411
            :|||||.|:|.||..:.|::|.|..|..|....|||:|..|::|||..|...:..||.|..||..
Mouse   349 VKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVL 413

  Fly   412 DIGENTVMRALKKALDKKFHDAAKVVSHSFH-HRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEM 475
            ::..:.:..|||..::.|.:....:...|.| .||.:.|..|::|||:|....|||.|:|:|.::
Mouse   414 EMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDL 478

  Fly   476 SRFVYYSLDVYAVLALVLGSIIASWVWLLRLCC---------GSSAAQKTKK 518
            :.:.|:||||...|.    :|:.:.|:::..||         |....:|:.|
Mouse   479 TWYQYHSLDVIGFLL----AIVLTVVFIVFKCCAYGCRKCFGGKGRVKKSHK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	131/508 (26%)
Ugt1a10	NP_964003.2	egt	14..502	CDD:223071	143/543 (26%)
Ugt1a10	NP_964003.2	UDPGT	26..521	CDD:278624	140/543 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840125
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.830