DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt49C1

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001036565.1	Gene:	Ugt49C1 / 37421	FlyBaseID:	FBgn0034605	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	160/547 - (29%)
Similarity:	279/547 - (51%)	Gaps:	48/547 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MWSPRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHF 65
            |..|.:..|.|...|....||.|.:   |:|.::..||.|||.....:::.|.|:||.|::|:.|
  Fly     1 MQFPLLFGLLLTGTLYSQLELAEGS---KILAVYAFPGKSHFMMHTALIRELVESGHQVTMVTAF 62

  Fly    66 P-DKHPV-AHYKDFPLTGMDKLTNSVDLKFFEKRTF----YSHFQEFFLLYDWGKQTCNLTLRSE 124
            . :|..: ::|.:..:..:....:.|.|.|..:..|    .:::....:|...|.:|....||..
  Fly    63 SLEKEQLGSNYTEILIEPVYDFWHDVKLNFGAQHLFELTRMTNYDFLKMLEIIGLKTTEHALRQP 127

  Fly   125 ALQQIL---RRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSC-----------VMMPWHYER 175
            .::.::   ::.|.||:::.|||..:..:.:||..:.||:..|:.           ::.||
  Fly   128 KVRSLIHAEQKEGVFDLLLAEQFYQEAFLALAHLYKIPVVTTSTLGYENHMSQMMGLITPW---- 188

  Fly   176 MGAPLIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLS-VPAADAMVQYKFG---HDVP 236
                   |.:|..||..:..|:|..|:.|.:::...: |.:||: .|..||:.:..||   .:||
  Fly   189 -------SFVPHGFMPFTDRMSFLERVKNSYASFYED-MDRLLNYFPKMDAVAREFFGPVLTEVP 245

  Fly   237 SVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNAEEGVILISWG 301
            .|..:.:..|:..:|.|..|:..:.|...::.:||:||...||||||:|.:||.|.||.|..|.|
  Fly   246 KVKHMERQISVMLLNSHAPLTTARPTVDAMVPVGGMHIYPPKPLPADMQALLDGATEGAIFFSLG 310

  Fly   302 SMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMS 366
            |.:::..:........::....|||:|:||:|:|::...|.|:.:.|||||.|||.|.:||||::
  Fly   311 SNVQSKDMPVEMLRLFLQVFGSLKQRVLWKFEDESISQLPDNVMVRKWLPQADILAHRHVKVFIT 375

  Fly   367 HGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKALDKKFH 431
            ||||.||.|..:..||::..|.|.||.:|....|..|....|:|:.|.|    ..|:.:||:..|
  Fly   376 HGGLFGTQEGVHYAVPMLGIPFYCDQHLNMNKAVLGGYAISLHFQSITE----EILRHSLDQLIH 436

  Fly   432 DA-----AKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAVLAL 491
            :.     .:.||..|..||.:...:|::|:|:|....||..::.:.::::.|.:|.|||.|.:|:
  Fly   437 NVTYKENVQRVSDIFRDRPLEPRKSAVYWIEYVIRHRGASHMRSAGLDLNWFQFYLLDVIAFVAI 501

  Fly   492 VLGSIIASWVWLLRLCCGSSAAQKTKK 518
            :..:.:.:....:||..||:...:..|
  Fly   502 IALAGVMALSLAIRLLMGSNKKHRKAK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	143/489 (29%)
Ugt49C1	NP_001036565.1	egt	22..504	CDD:223071	148/500 (30%)
Ugt49C1	NP_001036565.1	UDPGT	37..498	CDD:278624	141/476 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454687
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890