DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	154/551 - (27%)
Similarity:	250/551 - (45%)	Gaps:	78/551 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 PRVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDK 68
            |....||||...:|       ||.|.|:   |..| ||:.....|::.|:..||:|.||  .|:
  Rat    11 PLCVCLFLASGFAQ-------AGRLLVV---PMDG-SHWFTMQMIVEKLSHRGHEVVVV--IPE- 61

  Fly    69 HPVAHYKDFPLTGMDKLTNSV-----DLKFFEKRTFYSHFQ-------EFFLLYDWGK------- 114
              |:.:....|....| |.||     ||.:..|  |::|.|       .|.||...||
  Rat    62 --VSWHMGKSLNFTVK-TYSVSYTLEDLNYHFK--FFAHNQWKTQEVGMFSLLKHSGKGFFELLF 121

  Fly   115 QTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGA- 178
            ..|....:.:.|.:.|:: ..||.:.::.|:. |.:.:|.....|.:..|..:..  ||...||
  Rat   122 SHCRSLFKDKKLVEYLKQ-SSFDAVFLDPFDV-CGLILAKYFSLPSVVFSGGIFC--HYLDEGAQ 182

  Fly   179 -PLIPSHIPALFMAQSQHMNFGGRLAN------------WFSTHALNWMYKLLSVPAADAMVQYK 230
             |..||::|.:....:..|.|..|:.|            :|...|:....::|..|.
  Rat   183 CPSPPSYVPRILSKFTDTMTFKERVWNHLSYMKERAFCPYFFKTAVEIASEVLQTPV-------- 239

  Fly   231 FGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEG 294
                  ::.:|....|::.....:.|..|:...||::.:|||:..:.|||..:.:..:: :.|.|
  Rat   240 ------TMRDLFSPVSIWMFRTDFVLEFPRPVMPNMVYIGGINCHQGKPLSKEFEAYVNASGEHG 298

  Fly   295 VILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHP 359
            :::.|.|||:  :.:...|...|..|:.|:.|.|:|::......|...|..::|||||.|:|.||
  Rat   299 IVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHP 361

  Fly   360 NVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKK 424
            ..:.|::|.|..|..|....|||:|..|::|||..|...:..||.|..||..::..:.:..|||.
  Rat   362 KARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKT 426

  Fly   425 ALDKKFHDAAKVVSHSFH-HRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA- 487
            .::.|.:....:...|.| .||.:.|..|::|||:|....|||.|:|:|.:::.:.|:||||..
  Rat   427 VINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGF 491

  Fly   488 VLALVLGSII---ASWVWLLRLCCGSSAAQK 515
            :||:||..:.   .|..:..|.|.|.....|
  Rat   492 LLAIVLTVVFIVYKSCAYGCRKCFGGKGRVK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	135/495 (27%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	146/526 (28%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	80/242 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810