DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt3a2

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	XP_038959826.1	Gene:	Ugt3a2 / 294793	RGDID:	1564365	Length:	454	Species:	Rattus norvegicus

Alignment Length:	478	Identity:	128/478 - (26%)
Similarity:	220/478 - (46%)	Gaps:	63/478 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 HP---VAHYKDFPLTGMDKLTNSVDLK--FFEKRT---FYSHFQEFFLLYDWGKQTCNLTLRSEA 125
            ||   :.||:      :|.....|.|.  .||..|   .:.||.:.          ||..|..:.
  Rat    11 HPGNRIMHYR------VDLCPQKVKLNKLQFEHHTIVKIHRHFGDL----------CNHLLSRKD 59

  Fly   126 LQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGAPLIPSHIPALFM 190
            :.:.|:. ..||:::.|..:. |...:..:|....:...:..:....:|....||  |::|....
  Rat    60 IMEFLKN-ANFDLVLFESVDY-CSSLIVEKLGKQFVLFLAFQLGFMDFELQRVPL--SYVPVYGS 120

  Fly   191 AQSQHMNFGGRLANWFSTHALNWMYK-LLSVPAADAMVQYKFGH-DVPSVGELVKNTSMFFVNQH 253
            ..:..|:|.||:.|:.....|:...: :||  ..|:.:|..|.. ..|.:.:|:....::|||..
  Rat   121 GLTDQMDFWGRVKNFLMFFDLSRKQREILS--QYDSTIQEHFAEGSRPVLSDLLLKAELWFVNCD 183

  Fly   254 YSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDN-AEEGVILISWGSMIRANSLSAAKRDGI 317
            ::....:...||::.:||:..:..:.:|.||:..:.. .:.|.:|::.|::  |......:   |
  Rat   184 FAFEFARPLFPNIVYVGGLLDKPVQSIPQDLENFITQFGDSGFVLVALGTV--ATKFQTKE---I 243

  Fly   318 IR----AVARLKQKVIWKWENETLPNQ---PPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSE 375
            |:    |.|.|.|.|||..::...|..   .||:.||.||||.|:|.||::::|::|||:...:|
  Rat   244 IKEMNNAFAHLPQGVIWACKDSHWPKDVTLAPNVKIMDWLPQTDLLAHPSIRLFVTHGGMNSVNE 308

  Fly   376 AAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL-DKKFHDAA---KV 436
            |...|||:|....:.||..|...:..:.:|..:..:.:...|..|.:|:.: ||::..||   |:
  Rat   309 AIQHGVPMVGILFFSDQPENMIRVEAKTIGVSIQIQTLKAETFARTMKEVIEDKRYKSAAMASKI 373

  Fly   437 VSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGSIIASW 500
            :.||....|.|.|.   .|::|:..||||..|||.|.:......|.|||:. :|.|.||:
  Rat   374 IRHSHPLTPSQRLE---GWIDHILQTGGAAHLKPYAFQQPWHEQYLLDVFLFLLGLTLGT----- 430

  Fly   501 VWLLRLCCGS-----SAAQKTKK 518
            |||.....|:     |.|:|.|:
  Rat   431 VWLCVKVLGAVMRYLSGARKAKQ 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	112/434 (26%)
Ugt3a2	XP_038959826.1	Glycosyltransferase_GTB-type	49..419	CDD:415824	102/393 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740