DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and ugt-30

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_506729.1	Gene:	ugt-30 / 187955	WormBaseID:	WBGene00011340	Length:	535	Species:	Caenorhabditis elegans

Alignment Length:	563	Identity:	133/563 - (23%)
Similarity:	242/563 - (42%)	Gaps:	89/563 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDKHPV 71
            :::|..|.|        .:..|.:|...|....||..|...:...|.|.||:|:.:.      ||
Worm     6 SIIFFCLLL--------YSNCLNILVYAPAFAASHSKFLGKLADTLTERGHNVTYLM------PV 56

  Fly    72 AHY-KDFPLTGMDKLTNSVDL-----KFFEKRTF-----------------YSHFQEFFLLY--D 111
            .:. |.....|: |:|..|.:     |...::..                 .|:.:|.|..:  |
Worm    57 VNIAKRDECKGV-KITKDVVIVEAGEKMLSQKQADTPNDEILDVWWTVQMDSSNSREIFQFFCSD 120

  Fly   112 WGKQTC-NLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQL--QAPVIALSSC---VMMP 170
            . |..| |...|.:..:.:..|  .||:.|:|..:. |.:|....|  :..::|.||.   |::|
Worm   121 M-KIACENFLSRRDIFEDMKAR--NFDLAILEPVSA-CGLGFVKALGIEKTILASSSVFYDVILP 181

  Fly   171 WHYERMGAPLIPSHIPALFMAQSQHMNFGGRLANWFSTH----ALNWMYKLLSVPAADAMVQYK- 230
            :    :|.||..|::|:.:....|.::.|.:..||..:.    ||..::.       ..|..|:
Worm   182 Y----IGEPLDYSYVPSGYSVTGQELSLGEKFENWMVSREISIALEGLFD-------GEMEIYRR 235

  Fly   231 -FGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIH----IQKSKPLPADLQRILDN 290
             .||::.:...|..:.|:||||.:.....|:......:.:|||.    ::|...|..:.:::| |
Worm   236 LLGHNLTNWRHLFPSASIFFVNSNPFFDFPRPVLEKTVPIGGISVNMGVRKEDMLTEEWEKVL-N 299

  Fly   291 AEEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQ-KVIWKWENE--TLPNQPPNMHIMKWLPQ 352
            .....:|:|:|:::.:..:....|.|::.|...... ..|||:|::  :..|...|::..||:||
Worm   300 QRPHTMLVSFGTLVMSTHMPKKWRSGLLEAFKSFPNVTFIWKYESDDHSFANGIDNIYFSKWVPQ 364

  Fly   353 RDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENT 417
            .::|....:..|:|||||....|.|:.|.|.:..|::.||..|...|. |..|.|...:...:||
Worm   365 NELLNDNRLTAFLSHGGLGSIMELAFSGKPALIIPVFADQTRNANTLA-RHRGAICLHKSQMKNT 428

  Fly   418 VMRALKKA-----LDKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSR 477
              ..||||     .|..|.:.:..::.:..::|.:...|.|.:.|.|...|..|.:.|....::.
Worm   429 --EVLKKAFKSVLFDASFKNNSLKLAATLRNQPNKPKDTLIKYTEFVGEFGPFPQMDPYGRHLNV 491

  Fly   478 FVYYSLDVYAVLALVLGSIIASWVW-----LLRLCCGSSAAQK 515
            |....:|:| .|.:|:.||..:.::     |::....|.:::|
Worm   492 FQKSFIDIY-TLIIVVSSIFVALIFNVIAKLIQYFIKSKSSEK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	121/509 (24%)
ugt-30	NP_506729.1	UDPGT	21..529	CDD:278624	127/534 (24%)
ugt-30	NP_506729.1	Glycosyltransferase_GTB_type	<255..524	CDD:299143	70/273 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161388
Domainoid	1	1.000	172	1.000	Domainoid score	I2232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.790