DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36D1 and ugt-22

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_502633.1	Gene:	ugt-22 / 178330	WormBaseID:	WBGene00007455	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	156/560 - (27%)
Similarity:	249/560 - (44%)	Gaps:	80/560 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLFLALALSQPDELVEAAGPLKVL---GLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDKH 69
            ||.|.|.|.....|.|   |.|:|   .||.|   ||......:...|.:||||::|:.
Worm     7 LLPLLLLLGSFVGLTE---PYKILMYTNLFGH---SHIKMLGAVSDTLTDAGHDLTVLM------ 59

  Fly    70 PVAHYKDFPLTGMDKLTNSVDL--------------KFFEKRTFYSHFQEFFLLYD-------WG 113
            ||..:|....|.|....|.:.:              ||..:.....:....|:::.       :.
Worm    60 PVIDFKQENKTAMKSTKNIIKIQPGQDISKTIETMEKFMTQLWTTDNSNPLFMVFHAPAMSAIFA 124

  Fly   114 KQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGV--AHQLQAPVIALSSCVMMPWHYERM 176
            .| |...|..:.|.:.||.. .||:.|.|.|:| |...:  |.:::|.| |:.||..:....:.:
Worm   125 SQ-CRKVLEDKELIERLRAE-NFDLAITEPFDT-CAYALFEAIKIRAHV-AVLSCSRLDHVSKAI 185

  Fly   177 GAPLIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFGHD------- 234
            |.|:.||::|.   .||.|   |.|:..|  ...:|.::.|:    .|.:..|....|
Worm   186 GQPIAPSYVPG---TQSTH---GERMTIW--QRFMNILHFLM----GDFLFSYIGDEDFKVAKEI 238

  Fly   235 VPSV---GELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHI---QKSKPLPADLQRILDNAEE 293
            :|.|   .|::...|..|.|....:..|..|...:|.:|||.:   :||..||....:||...::
Worm   239 IPGVRSWREVLPEASFIFTNHIPLMDFPAPTFDKIIPIGGISVKTQKKSLELPEKWNKILGLRKK 303

  Fly   294 GVILISWGSMIRANSLSAAKRDGIIRAVARLKQ-KVIWKWENE--TLPNQPPNMHIMKWLPQRDI 355
            . ||:|:||..|:..:....:..:::....:.. ..|||:|||  ||.:...|:::..||||.::
Worm   304 N-ILVSFGSNARSADMPEHFKQNVLKVAESMPDVTFIWKYENEKDTLADHLDNVYLGDWLPQNEL 367

  Fly   356 LCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGE-NTVM 419
            |..|.:.:|::||||...:|.|..|.|.|..|::.||..|...|...|...:|:..|:|. .|:.
Worm   368 LGDPRLSLFVTHGGLASVTELALMGKPAVMVPLFADQARNANMLKRHGGAAVLHKTDLGNAETIR 432

  Fly   420 RALKKALD-KKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSL 483
            ..:||.|: :|:...|:.::...:::|.....|.|..||..|..|..|.:.|.....|...||.|
Worm   433 NTIKKVLENEKYRVNAERLAEMLNNQPTNPKDTLIKHVEFAAKFGQLPSMDPYGRHQSYIEYYLL 497

  Fly   484 DVYAV-LALVLGSIIASWVWL---LRLCCGSSAAQKTKKD 519
            |:.:: |.|:|.:...|:..:   .|:||||.   |.|||
Worm   498 DIISIALVLILTTSFISFQLIKCTFRMCCGSG---KVKKD 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	135/504 (27%)
ugt-22	NP_502633.1	UDPGT	36..530	CDD:278624	139/519 (27%)
ugt-22	NP_502633.1	egt	<256..515	CDD:223071	77/259 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161369
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.790