DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36D1 and ugt-25

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_491438.1	Gene:	ugt-25 / 172087	WormBaseID:	WBGene00015692	Length:	531	Species:	Caenorhabditis elegans

Alignment Length:	518	Identity:	126/518 - (24%)
Similarity:	230/518 - (44%)	Gaps:	70/518 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDKH-----PVAHYKDFPLTGMDKLTNS- 88
            :|...|..|.||.:|...:...|.||||:|:.|....|:.     .|...||..:...|:|..|
Worm    20 ILVYSPSFGGSHTNFMARLADTLTEAGHNVTFVVPVADEARKGQLGVKKTKDVVIVEQDELMKSE 84

  Fly    89 -------------VDLKFFEKRTFYSHFQEFFLLYDWGKQTCNLTLRSEALQQILRRPGRFDVII 140
                         .|:......:.:|.|.:..||      :||..:|::.:...| :...|||.|
Worm    85 IKPLDDDMAQYWETDMDSSNADSIFSVFSDAMLL------SCNNFMRNKKVFNEL-KSRNFDVGI 142

  Fly   141 MEQFNTDCMMGVAHQLQA-PVIALSSCVMMPWHYERMGAPLIPSHIPALFMAQSQHMNFGGRLAN 204
            .|..:. |.:|..|.:.. .:|..|||.:.......:|.|:..|::|.......:.|:...:|.|
Worm   143 YEPLSV-CGLGYMHAIGINKLIMSSSCALYDGTVAAIGEPIDFSYVPGSMSKSGEKMSLFEKLEN 206

  Fly   205 WFSTHALNWMYKLLSVPAADAMVQY------------KFGHDVPSVGELVKNTSMFFVNQHYSLS 257
                      |:|   ..|.:.:||            ..|:|:|...:|:.::|:.|.|....:.
Worm   207 ----------YRL---SMASSRMQYGQWDKETEIYKKHLGNDIPHWRDLMPSSSVAFTNSIPYVD 258

  Fly   258 GPKVTPPNVIELGGIHIQ----KSKPLPADLQRILDNAEEGVILISWGSMIRANSLSAAKRDGII 318
            .|:......:.:|||.:.    ||:.|..:...:||..... :|||:|||:|:..:....|:|::
Worm   259 FPRSITQKTVPIGGISVDMEMIKSQKLSIEWSTVLDERPHN-MLISFGSMVRSMDMPLKWRNGLL 322

  Fly   319 RAV-ARLKQKVIWKWENETL--PNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCG 380
            .|: :......|||:||:.|  .....|::..||:||..:|....:..||:||||..|:|.|:.|
Worm   323 EAIKSEPNVTFIWKYENDNLEWAKGIQNIYFSKWVPQTALLNDARLTAFMTHGGLGSTNELAFLG 387

  Fly   381 VPVVATPMYGDQFVNTAALVERGMGTILNFEDIGE-NTVMRALKKAL-DKKFHDAAKVVSHSFHH 443
            .|.:..|::.||..|...|...|...:::.:::|. .|:..:::..| ::|:...|:.:|...::
Worm   388 KPALMVPVFADQDRNANMLARHGGVLVVHKKELGNFKTIKSSIRSILHEEKYQKNARKLSELLNN 452

  Fly   444 RPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAVLALVLGSIIASWVWLLRL 506
            :|.:.....:.:.|.||..|..|.:.....::.......:|:||.::|       |:::::.|
Worm   453 QPLKPKEQVVKYTEFVAKFGPFPQMDSYGRQLGFIQRNLIDIYAAISL-------SYLFVISL 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	120/492 (24%)
ugt-25	NP_491438.1	egt	1..477	CDD:223071	120/478 (25%)
ugt-25	NP_491438.1	UDPGT	29..530	CDD:278624	123/509 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	172	1.000	Domainoid score	I2232
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	172	1.000	Inparanoid score	I2735
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.860