Protein Alignment Ugt36D1 and UGT3A2

DIOPT Version :10

• Sequence 1: NP_609910.1
• Gene: Ugt36D1 / 35138
• FlyBaseID: FBgn0032713
• Length: 519
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 587
• Identity: 146/587 - (24%)
• Similarity: 246/587 - (41%)
• Gaps: 107/587 - (18%)

  Fly     1 MWSPRVALL--FLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVS 63
            |...||.||  ||.     |..|:..|..:..:...   |.||:.....:.:.|.:.||:|::::
Human     1 MAGQRVLLLVGFLL-----PGVLLSEAAKILTISTV---GGSHYLLMDRVSQILQDHGHNVTMLN 57

  Fly    64 H-----FP---------DKHPVAHY---------KDF--------------PLTGMDKLTNSVDL 91
            |     .|         .::|...|         |||              |.....:...|.|
Human    58 HKRGPFMPGLSDSPASASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPEDHQREFKKSFD- 121

  Fly    92 KFFEKRTF--YSHFQEFFLLYDWGKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAH 154
             ||.:.|.  ...|:....:.::....|:..|..:.:...|:.. .||::|:|.|:. |...:|.
Human   122 -FFLEETLGGRGKFENLLNVLEYLALQCSHFLNRKDIMDSLKNE-NFDMVIVETFDY-CPFLIAE 183

  Fly   155 QLQAPVIALSSCVMMPWHYERMGAPLIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLS 219
            :|..|.:|:.|.......:   |.|:..|::|......:.||:|.||:.|:.         ...|
Human   184 KLGKPFVAILSTSFGSLEF---GLPIPLSYVPVFRSLLTDHMDFWGRVKNFL---------MFFS 236

  Fly   220 VPAADAMVQYKFGHDV---------PSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQ 275
            .......:|..|.:.:         |.:..|:....::|:|..::....:...||.:.:||:..:
Human   237 FCRRQQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPNTVYVGGLMEK 301

  Fly   276 KSKPLPADLQRILDN-AEEGVILISWGSMIRANSLSAAKRDGIIR----AVARLKQKVIWKWENE 335
            ..||:|.||:..:.. .:.|.:|::.|||:     :..:...|.:    |.|.|.|.||||.:..
Human   302 PIKPVPQDLENFIAKFGDSGFVLVTLGSMV-----NTCQNPEIFKEMNNAFAHLPQGVIWKCQCS 361

  Fly   336 TLPNQ---PPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTA 397
            ..|..   ..|:.|:.||||.|:|.||::::|::|||.....||...|||:|..|::|||..|..
Human   362 HWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFGDQPENMV 426

  Fly   398 ALVERGMGTILNFEDIGENTVMRALKKAL-DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAH 461
            .:..:..|..:..:.:...|:...:|:.: ||::..||...|......|.......:.|::||..
Human   427 RVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVGWIDHVLQ 491

  Fly   462 TGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGSIIASW---------VWLLRLCCGSSAAQKT 516
            ||||..|||...:......|.|||:. :|.|.||::   |         ||.||      .|:|.
Human   492 TGGATHLKPYVFQQPWHEQYLLDVFVFLLGLTLGTL---WLCGKLLGMAVWWLR------GARKV 547

  Fly   517 KK 518
            |:
Human   548 KE 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_609910.1	GT1_Gtf-like	28..457	CDD:340817	111/485 (23%)
UGT3A2	XP_011512290.1	Glycosyltransferase_GTB-type	23..518	CDD:471961	124/518 (24%)