DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36D1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_569091.2	Gene:	Ugt1a7c / 154516	RGDID:	620950	Length:	531	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	147/537 - (27%)
Similarity:	242/537 - (45%)	Gaps:	84/537 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDKHPVAHYKDFPLTGMDKLTNSV 89
            ||.|.|:   |..| ||:.....:::.|...||:|.||  .|:   |:.....||.
  Rat    25 AGKLLVV---PMDG-SHWFTMQMVVEKLLPKGHEVVVV--VPE---VSWQLGKPLN--------- 71

  Fly    90 DLKFFEKRTF-YSHFQE-------FFLLYDWGKQT----------------------CNLTLRSE 124
                |..:|: .||.||       ||:...|..|.                      |....:.:
  Rat    72 ----FTVKTYSVSHTQEDLNREFKFFIDSQWKTQQEGGVLPLLTSPAQGFFELLFSHCRSLFKDK 132

  Fly   125 ALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHYERMGA--PLIPSHIPA 187
            .|.:.|:: ..||.:.::.|:. |.:.||.....|.:..|..:..  ||...|:  |..||::|.
  Rat   133 KLVEYLKQ-SSFDAVFLDPFDV-CGLTVAKYFSLPSVVFSRGIFC--HYLEEGSQCPSPPSYVPR 193

  Fly   188 LFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYKFGHDVPS--------VGELVKN 244
            ..:..:..|.|..|:.|     .|::|.:....|:.     :|...|:.|        :.:|...
  Rat   194 GILKLTDTMTFKERVWN-----LLSYMGEHAFCPSF-----FKTATDIASEVLQTPVTMTDLFSP 248

  Fly   245 TSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVILISWGSMIRANS 308
            .|::.:...::|..|:...||||.:|||:..:.|||..:.:..:: :.|.|:::.|.|||:  :.
  Rat   249 VSVWLLRTDFTLELPRPVMPNVIHIGGINCHQRKPLSKEFEAYVNASGEHGIVVFSLGSMV--SE 311

  Fly   309 LSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGT 373
            :...|...|..|:.|:.|.|:|::......|...|..::|||||.|:|.||..:.|::|.|..|.
  Rat   312 IPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGI 376

  Fly   374 SEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKALDKKFHDAAKVVS 438
            .|....|||:|..|::|||..|...:..||.|..||..::..:.:..|||..::.|.:....:..
  Rat   377 YEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRL 441

  Fly   439 HSFH-HRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGSII---A 498
            .|.| .||.:.|..|::|||:|....|||.|:|:|.:::.:.|:||||.. :||:||..:.   .
  Rat   442 SSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYK 506

  Fly   499 SWVWLLRLCCGSSAAQK 515
            |..:..|.|.|.....|
  Rat   507 SCAYGCRKCFGGKGRVK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	134/498 (27%)
Ugt1a7c	NP_569091.2	UDPGT	26..522	CDD:278624	145/533 (27%)
Ugt1a7c	NP_569091.2	egt	<264..505	CDD:223071	82/242 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810