DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt1a6

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001034780.1	Gene:	Ugt1a6 / 113992	RGDID:	620949	Length:	530	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	152/530 - (28%)
Similarity:	248/530 - (46%)	Gaps:	74/530 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 VLG----LFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPDKHPV----AHY--KDFPLTGMDK 84
            |||    :.|..| ||:.....|::.|:|.|||:.|:  .|:.:.:    .:|  |.||
  Rat    23 VLGDKLLVVPQDG-SHWLSMKEIVEHLSERGHDIVVL--VPEVNLLLGESKYYRRKSFP------ 78

  Fly    85 LTNSVDLKFFEKRTFY-----SHF----------QEF---FLLYDWGKQTCNLTLRSEALQQILR 131
                |.....|.||.|     :||          :|:   .::.|....:|...|:..|....||
  Rat    79 ----VPYNLEELRTRYRSFGNNHFAASSPLMAPLREYRNNMIVIDMCFFSCQSLLKDSATLSFLR 139

  Fly   132 RPGRFDVIIMEQFNTD----CMMGVAHQLQAPVIALSSCVMMPWHYERM--GAPLIPSHIPALFM 190
            . .:||.:.     ||    |.:.:|..|:.|.:.|..  ..|...|.|  .:|...|::|..:.
  Rat   140 E-NQFDALF-----TDPAMPCGVILAEYLKLPSVYLFR--GFPCSLEHMLGQSPSPVSYVPRFYT 196

  Fly   191 AQSQHMNFGGRLANWFSTHALNWMYKLL----SVPAADAMVQYKFGHDVPSVGELVKNTSMFFVN 251
            ..|.||.|..||||:.:....|::|..|    .:.|:|.:.:     || |:..|.:| |::.:.
  Rat   197 KFSDHMTFPQRLANFIANILENYLYHCLYSKYEILASDLLKR-----DV-SLPALHQN-SLWLLR 254

  Fly   252 QHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILD-NAEEGVILISWGSMIRANSLSAAKRD 315
            ..:....|:...||:|.:||.:.:|...|..:.:..:: :.|.|:::.|.|||:  :.:...|..
  Rat   255 YDFVFEYPRPVMPNMIFIGGTNCKKKGNLSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAM 317

  Fly   316 GIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVKVFMSHGGLMGTSEAAYCG 380
            .|..|:.|:.|.|:|::......|...|..::|||||.|:|.||..:.|::|.|..|..|....|
  Rat   318 EIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNG 382

  Fly   381 VPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKALDKKFHDAAKVVSHSFH-HR 444
            ||:|..|::|||..|...:..||.|..||..::..:.:..|||..::.|.:....:...|.| .|
  Rat   383 VPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDR 447

  Fly   445 PQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLALVLGSII---ASWVWLLR 505
            |.:.|..|::|||:|....|||.|:|:|.:::.:.|:||||.. :||:||..:.   .|..:..|
  Rat   448 PIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKSCAYGCR 512

  Fly   506 LCCGSSAAQK 515
            .|.|.....|
  Rat   513 KCFGGKGRVK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	139/491 (28%)
Ugt1a6	NP_001034780.1	egt	14..504	CDD:223071	147/510 (29%)
Ugt1a6	NP_001034780.1	UDPGT	26..521	CDD:278624	148/524 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810