DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and Ugt2b34

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_705826.1	Gene:	Ugt2b34 / 100727	MGIID:	2140962	Length:	532	Species:	Mus musculus

Alignment Length:	547	Identity:	154/547 - (28%)
Similarity:	267/547 - (48%)	Gaps:	66/547 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSV------VSHF 65
            |||.|.|.||   ....:....||| ::|.. .||:.....|:..|.:.||:|.|      :|:.
Mouse     8 ALLLLLLQLS---GFFGSGTGGKVL-VWPME-FSHWLNLKTILDELLKKGHEVMVLRPSASLSYE 67

  Fly    66 PDKHPVAHYKDFP----LTGMDKL-TNSVDLKFFE--KRTFYSHF---QEF-FLLYDWGKQTCNL 119
            .|......::.:|    |:.:::: ..|:....:|  |::|:.:|   ||. ::...:.:..|..
Mouse    68 VDNTSAIEFETYPTSYSLSELEEIFWESLKKYIYELPKQSFWGYFLMLQEMVWVDSKYFESLCKD 132

  Fly   120 TLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWH-YERM--GAPLI 181
            .:.::.|...|:: .|||||:.:.| ..|...:|..|:.|::  .|....|.. ||:.  |.||.
Mouse   133 VVFNKELMTKLQK-SRFDVILADPF-IPCGDLLAEVLKIPLV--YSLRFFPGSTYEKYSGGLPLP 193

  Fly   182 PSHIPALFMAQSQHMNFGGRLAN---------WFST-HALNW--MY-KLLSVPAADAMVQYKFGH 233
            ||::|.:....|..|.|..|:.|         ||.| :..||  :| ::|..|.
Mouse   194 PSYVPVVMSELSDRMTFMERVRNVIYMLCFDFWFQTFNEKNWNQLYTEVLGRPT----------- 247

  Fly   234 DVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNA-EEGVIL 297
               ::.|.:....::.:..::.|..|....||...:||:|.:.:||||.:::..:.:: |.||::
Mouse   248 ---TLSETMAKADIWLIRTYWDLEFPHPVLPNFDFIGGLHCRPAKPLPKEIEDFVQSSGEHGVVV 309

  Fly   298 ISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPNVK 362
            .|.|||:  .|::..:.:.|...:|::.|||:|::|.:.......|..:.||:||.|:|.|...:
Mouse   310 FSLGSMV--GSITEERANVIAAGLAQIPQKVLWRFEGKKPETLGSNTRLYKWIPQNDLLGHSKTR 372

  Fly   363 VFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKAL- 426
            .|::|||..|..||.|.|:|||..|::|||:.|...|..:|....|:|..:....:..|||...
Mouse   373 AFITHGGTNGIYEAIYHGIPVVGIPLFGDQYDNIVHLKAKGAAVRLDFLTMSSTDLHTALKTVTN 437

  Fly   427 DKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYA-VLA 490
            |..:.:.|..:|...|.:|.:.|..|::|:|.|....||..|:.:|.::|...|:||||.. :||
Mouse   438 DPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWVQYHSLDVLGFLLA 502

  Fly   491 LVLGSIIASWVWLLRLCCGSSAAQKTK 517
            .||     :.:::|:.||.....:.||
Mouse   503 CVL-----TVMFILKKCCLFCCQKLTK 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	134/495 (27%)
Ugt2b34	NP_705826.1	UDPGT	27..529	CDD:278624	147/525 (28%)
Ugt2b34	NP_705826.1	egt	<272..510	CDD:223071	80/244 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840136
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740