DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36D1 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	554	Identity:	143/554 - (25%)
Similarity:	246/554 - (44%)	Gaps:	81/554 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 WSPRVALLFLALALSQPDELVEAAGPLKVLGLFPHPG-VSHFHFFHPIMKGLAEAGHDVSVV--S 63
            ||.||.::                           || .||:|....|::.|.:..|.|:|:  |
Zfish    19 WSGRVLVM---------------------------PGEYSHWHNMRAIIEALVDRNHSVTVLVGS 56

  Fly    64 HFP----------DKHPV----------AHYKDFPLTGMDKLTNSVDLKFFEKRTFYSHFQEFFL 108
            ..|          |.|..          |.:.||....|    |....|:......:.....|..
Zfish    57 SSPTVPHTQKARFDYHVFKVNIEKEEADAVWSDFIYLWM----NETATKYETVSNIFQVMSRFMT 117

  Fly   109 LYDWGKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIALSSCVMMPWHY 173
            |.|   :.|....:.:.||.:  |...:||:..:.. ..|...:|..|..|:: ||......:.:
Zfish   118 LTD---EVCKGMFKEDLLQML--RESHYDVLFSDPM-MPCSDLMAQTLNIPLV-LSLRATFAYSF 175

  Fly   174 ERM--GAPLIPSHIPALFMAQ--SQHMNFGGRLAN---WFSTHALNWMYKLLSVPAADAMVQYKF 231
            |||  ..|..||::||..:..  :..|:|..|:.|   :||......:|.:.:.......::.|
Zfish   176 ERMCGQMPAPPSYVPAASLRDHLTDRMSFMERVENMLLYFSHDVFFKLYMMFTFDRIYTEIRGK- 239

  Fly   232 GHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNA-EEGV 295
               ..::.|.:....::.:..::....|:..|||...:||:|.:.:|||..:::..:.:: :.||
Zfish   240 ---PTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKEMEEFVQSSGDHGV 301

  Fly   296 ILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHPN 360
            ::.|.||||:  :|::.:.:.|..|:.::.|||:|::..:|.....||..|..|:||.|:|.||.
Zfish   302 VVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPK 364

  Fly   361 VKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNFEDIGENTVMRALKKA 425
            .|.|::|||..|..||.|.|||:|..|::.||..|...:..:|...:|:...:....::.|||..
Zfish   365 TKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTV 429

  Fly   426 LDK-KFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYYSLDVYAVL 489
            |:. .:.::...:|...|.:|.:.|..|::|:|.|....||..|:..|.|:|.:.|:.|||.|.|
Zfish   430 LNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFL 494

  Fly   490 ALVLGSIIASWV----WLLRLCCGSSAAQ-KTKK 518
            ..:...|...||    :|.|.|...:..: ||:|
Zfish   495 LSIAALITFLWVKACCFLFRRCVRKTRPERKTQK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	125/492 (25%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	138/541 (26%)
		REC	<129..>178	CDD:302758	12/52 (23%)
		egt	<254..485	CDD:223071	72/232 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584371
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.930