DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36D1 and ugt2b3

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170812.2	Gene:	ugt2b3 / 100384898	ZFINID:	ZDB-GENE-100402-2	Length:	527	Species:	Danio rerio

Alignment Length:	562	Identity:	146/562 - (25%)
Similarity:	261/562 - (46%)	Gaps:	83/562 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVVSHFPD-- 67
            |:.:.||:|.      .|.:||....: |..|...||:.....::..|.:.||:|:|:  .||
Zfish     2 RLVVCFLSLL------TVFSAGQCGNI-LVWHTEGSHWINLKIVLDTLLDRGHNVTVL--MPDGA 57

  Fly    68 ------KHPVAHYKDFPLTGMDKLTNSVDLK-FFEKRTFYSHFQ-----------EFFLL----Y 110
                  :.....|::|.::     |::.|:: |.::...:|.|:           :||.|    .
Zfish    58 LFMKAKESDRFSYQNFSVS-----TSAQDMQDFLDELLHFSVFEMEQLNLLQIQMKFFDLGSRHQ 117

  Fly   111 DWGKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVIAL----------SS 165
            |.|...|:..|:|..|...| :.|:|||::.:.. ..|...||..|..|::..          ..
Zfish   118 DMGLSYCDGILKSPELMDKL-KTGKFDVLLSDPM-YPCSDIVAEVLNVPLVFTLRFSIAHTMERI 180

  Fly   166 CVMMPWHYERMGAPLIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMVQYK 230
            |..:|       ||  ||::|......:..|:|..|:.|.....::: .:.:::....|......
Zfish   181 CGQIP-------AP--PSYVPGAMSKLTDKMSFTERIFNTLFYLSMD-TFSIIAWKKFDNYYTEY 235

  Fly   231 FGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNA-EEG 294
            ||... |..|::....::.:..::....|:...||...:||:|...:||||.|::..:.:: ::|
Zfish   236 FGRPT-SYCEMMGRADIWLIRTYWDFEFPRPFVPNFKYIGGLHCTPAKPLPKDMEEFVQSSGDDG 299

  Fly   295 VILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDILCHP 359
            :::.:.||||  :.:.....:.|..|:|::.|||:|::..|.......|..|.||:||.|:|.||
Zfish   300 IVVFTLGSMI--DKVPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIYKWMPQNDLLGHP 362

  Fly   360 NVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNF------EDIGE--N 416
            ..:.|::|||..|..||.|.|||:|..|::|||..|...:..||...:::.      :::.:  |
Zfish   363 KTRAFITHGGTNGIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVDKLN 427

  Fly   417 TVMRALKKALDKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRFVYY 481
            ||:.      |..:.:.|..:|...|.||.:.|..:::|:|.|....||..|:..|..::.:.|:
Zfish   428 TVIN------DPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWYQYH 486

  Fly   482 SLDVYA----VLALVLGSIIASWVWLLRLCCGSSAAQKTKKD 519
            .|||:|    ||.|||........:.:..||..| .:|:||:
Zfish   487 CLDVFAFLTTVLTLVLYICFKMAKFFIMRCCFRS-KRKSKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	127/503 (25%)
ugt2b3	NP_001170812.2	UDPGT	20..523	CDD:278624	136/532 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584351
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.740