DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36D1 and ugt2b1

DIOPT Version :9

Sequence 1:	NP_001246082.2	Gene:	Ugt36D1 / 35138	FlyBaseID:	FBgn0032713	Length:	519	Species:	Drosophila melanogaster
Sequence 2:	NP_001170809.1	Gene:	ugt2b1 / 100384895	ZFINID:	ZDB-GENE-100402-1	Length:	527	Species:	Danio rerio

Alignment Length:	566	Identity:	146/566 - (25%)
Similarity:	264/566 - (46%)	Gaps:	91/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVALLFLALALSQPDELVEAAGPLKVLGLFPHPGVSHFHFFHPIMKGLAEAGHDVSVV------- 62
            |:.:.||:|.      .|.:||....:.::...| ||:.....::..|.:.||:|:|:
Zfish     2 RLVVCFLSLL------TVFSAGQCGNILVWYTEG-SHWINLKIVLDTLLDRGHNVTVLMPDGALF 59

  Fly    63 -----------SHFPDKHPVAHYKDFPLTGMD--------KLTNS----VDLKFFEKRTFYSHFQ 104
                       .||.........:||    :|        :|.||    :.:|||:   ..|..|
Zfish    60 MKAKESDRFSYQHFSVSTSAQDMQDF----LDEFLHFSVFELENSNLLQIQMKFFD---LLSKHQ 117

  Fly   105 EFFLLYDWGKQTCNLTLRSEALQQILRRPGRFDVIIMEQFNTDCMMGVAHQLQAPVI-----ALS 164
            :..|.|      |:..|:|..|...|:: |:|||::.:.. ..|...||.:|..|::     :|:
Zfish   118 DMSLSY------CDGILKSPELMDKLKK-GKFDVLLSDPM-YPCSDIVAEELNVPLVYTFRFSLA 174

  Fly   165 SCVMMPWHYERM--GAPLIPSHIPALFMAQSQHMNFGGRLANWFSTHALNWMYKLLSVPAADAMV 227
            ..:      |||  ..|..|||:|......:..|:|..|:.:.....:::..|:|:.....:...
Zfish   175 HTM------ERMCGQIPAPPSHVPGATSKLTDKMSFTERICSMLFYLSIDTFYRLIWKRFDNYYT 233

  Fly   228 QYKFGHDVPSVGELVKNTSMFFVNQHYSLSGPKVTPPNVIELGGIHIQKSKPLPADLQRILDNA- 291
            :| .|... |..|::....::.:..::....|:...||...:||:|...:||||.|::..:.::
Zfish   234 EY-LGRPT-SYCEMMGRADIWLIRTYWDFEFPRPFVPNFKYIGGLHCTPAKPLPKDMEEFVQSSG 296

  Fly   292 EEGVILISWGSMIRANSLSAAKRDGIIRAVARLKQKVIWKWENETLPNQPPNMHIMKWLPQRDIL 356
            ::|:::.:.||||  :.:.....:.|..|:|::.|||:|::..|.......|..|.||:||.|:|
Zfish   297 DDGIVVFTLGSMI--DKVPKEMSNRIASALAQIPQKVLWRYGGEKPDTLGENTRIYKWMPQNDLL 359

  Fly   357 CHPNVKVFMSHGGLMGTSEAAYCGVPVVATPMYGDQFVNTAALVERGMGTILNF------EDIGE 415
            .||..:.|::|||..|..||.|.|||:|..|::|||..|...:..||...:::.      :::.:
Zfish   360 GHPKTRAFITHGGTNGIYEAIYHGVPMVGIPLFGDQPDNMVHMTTRGAAVVVDSIKSMQPQELVD 424

  Fly   416 --NTVMRALKKALDKKFHDAAKVVSHSFHHRPQQALHTAIWWVEHVAHTGGAPLLKPSAVEMSRF 478
              |||:.      |..:.:.|..:|...|.||.:.|..:::|:|.|....||..|:..|..::.:
Zfish   425 KLNTVIN------DPSYKENAMRLSRIHHDRPMKPLDESVFWIEFVMRNKGAKHLRVEAHNLTWY 483

  Fly   479 VYYSLDVYAVLALVLGSII-----ASWVWLLRLCCGSSAAQKTKKD 519
            .|:.|||:|.|..||..::     .:..:::|.|..|.  :|:||:
Zfish   484 QYHCLDVFAFLTTVLTLVLYICSKMAKFFIMRCCFRSK--RKSKKE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36D1	NP_001246082.2	egt	21..482	CDD:223071	129/506 (25%)
ugt2b1	NP_001170809.1	UDPGT	20..523	CDD:278624	136/536 (25%)
ugt2b1	NP_001170809.1	egt	<264..497	CDD:223071	75/240 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000