DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36F1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	532	Identity:	146/532 - (27%)
Similarity:	251/532 - (47%)	Gaps:	74/532 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHFDFFRPMFLALAERGHNISMYSYFPLEKPVANY-------TDYVFQGMPLLTDIVDLSNFESE 90
            ||:...:.:...|.::||.:::.      :|.|:.       :|..|...|......||.||.:.
  Rat    34 SHWMNIKIILEELVQKGHEVTVL------RPSASVFLDPKETSDLKFVTFPTSFSSHDLENFFTR 92

  Fly    91 ----WKPLGLPFKVP-----TYFM--------LHDWGLRSCKVAL-NSPLITQLLKSPIRYDVIL 137
                |     .:::|     :||:        ..|:.|..||.|: |...:|:|.:|  ::||:
  Rat    93 FVNVW-----TYELPRDTCLSYFLYLQDTIDEYSDYCLTVCKEAVSNKQFMTKLQES--KFDVV- 149

  Fly   138 LEHFSN---DCMAAVAHLLNAPVIALSSCAIMPWH--YKRMGSPFINP-IMPMNFLPYTDEMSLI 196
               ||:   .|...:|.||..|.  |.|....|.:  .|.:|.....| .:||.|.....:|:.|
  Rat   150 ---FSDAIGPCGELIAELLQIPF--LYSLRFSPGYTIEKYIGGVLFPPSYVPMIFSGLAGQMTFI 209

  Fly   197 DRLNNFFHFHTVNTLYNMITQPATDALIAERFG-PGLPPINEIVKNTSLMLINQHYALTGPRPYA 260
            :|::|.......:..:....:...|...::..| |  ..:.||:....:.||..::.|..|.|.:
  Rat   210 ERVHNMICMLYFDFWFQTFREKKWDPFYSKTLGRP--TTLAEIMGKAEMWLIRSYWDLEFPHPIS 272

  Fly   261 PNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKEY 324
            |||..:|||...|.||||:.:.|.:..| .:||:..|.||||.:.|  ..|.:.:..:::|:.:
  Rat   273 PNVDYIGGLHCKPAKPLPKDIEDFVQSSGEHGVVVFSLGSMVRNMT--EEKANIIAWALAQIPQ- 334

  Fly   325 NFVMRWKSLESLEDKQP----SNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLV 385
                  |.|...:.|:|    .|...:.||||.|||.|||.:||::|||..|..||||.|:||:.
  Rat   335 ------KVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHGGANGIYEAIHHGIPMIG 393

  Fly   386 TPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIILDKKFAER-VRRSSEAFRQRPIPPI 449
            .|.:|:|..|...:..:|..|.|:||....:.:...|..:::..|.:: ....|.....:|..|:
  Rat   394 IPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFYKKNAMWLSTIHHDQPTKPL 458

  Fly   450 KLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLG-ILFLLIVALRKLIKIFKTAFCR 513
            ..|.:|||.|:::.||.|::|...::.|..|:|:||:.|.|. :...:::||:..:.::     |
  Rat   459 DRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFLLTCVAVTVVLALKCFLFVY-----R 518

  Fly   514 GKISRDTKTKTQ 525
            ..:.::.|||.:
  Rat   519 FFVKKEKKTKNE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	138/491 (28%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	127/460 (28%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	143/527 (27%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	76/227 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343995
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.790