DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and ugt2a6

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001138283.1	Gene:	ugt2a6 / 797211	ZFINID:	ZDB-GENE-081104-3	Length:	529	Species:	Danio rerio

Alignment Length:	537	Identity:	156/537 - (29%)
Similarity:	259/537 - (48%)	Gaps:	75/537 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PGK-SHFDFFRPMFLALAERGHNISMYSYFPLEKPVANYTD------YVFQGMPLLTDIVDL--S 85
            ||: ||:...||:..||.::.|::::  ......|...:|.      :||: :.:..::||.  .
Zfish    27 PGEYSHWHNMRPVIEALVDKNHSVTV--LVGSSSPTVPHTQKERFEYHVFK-VNMEKEVVDYLWI 88

  Fly    86 NFESEWKPLGLPFKVPTY-FMLHDWGLRSCKVALNSPLI-----TQLLKS--PIRYDVI---LLE 139
            :|...|    :...:.|| ..|..|.|.|...|.:..|:     ..|||:  ...|||:   |..
Zfish    89 HFHELW----MNETISTYEKTLEVWQLMSLFRAHSEELVKGLFDVGLLKTLRDSNYDVLFSDLTM 149

  Fly   140 HFSNDCMAA---VAHLLNAPVIALSS----CAIMPWHYKRMGSPFINPIMPMNFLP-------YT 190
            .|| |.||.   :.|:|:..:...|:    |..||              :|.:::|       .|
Zfish   150 PFS-DLMAQKLNIPHVLSMRISFASALERLCGQMP--------------VPQSYVPAAVAQGHLT 199

  Fly   191 DEMSLIDRLNNFFHFHTVNTLYNMITQPATDALIAERFGPGLPPIN--EIVKNTSLMLINQHYAL 253
            |.||..:|:.|...:.|...::.:.|:...|.:.||..|   .|..  |.:..|.:.||..::..
Zfish   200 DRMSFTERVENMLLYITHTAMFQLTTKFTFDHIYAEISG---EPTTMCETIGKTDIWLIRTYWDF 261

  Fly   254 TGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQS 317
            ..|||:.||...|||||..|.|||.:.|.:.:..| .:|::..|.|||:.:.|:.  |.:.:..:
Zfish   262 EYPRPFPPNFKFVGGLQCKPAKPLAKELEEFVQSSGDHGIVVFSLGSMIKNLTVQ--KANTIAAA 324

  Fly   318 ISQLKEYNFVMRW--KSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCG 380
            :.|:.: ..|.|:  |:.|:|    ..|...:||:||.|||.|||.:|||:|||..|..|||:.|
Zfish   325 LGQISQ-KVVWRYSGKTPETL----APNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHG 384

  Fly   381 VPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIILDK-KFAERVRRSSEAFRQR 444
            |||:..|.:|||..|...:|.:|..|::||...:|..:...|:.:|:. .:.|.:.|.|.....:
Zfish   385 VPMVGLPLFGDQPDNLMHLKSKGAAVVLDFFTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQ 449

  Fly   445 PIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLL-IVALRKLIKIFK 508
            |:.|:..|.:|||.|::..||.|::.:|..::|..|:.:||..|.|.|..|: .:.::....:|:
Zfish   450 PMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSITALITFLWVKACCFLFR 514

  Fly   509 TAFCRGKISRDTKTKTQ 525
            .  |..|...:.|:|.:
Zfish   515 R--CVRKTRPERKSKKE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	147/496 (30%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	135/461 (29%)
ugt2a6	NP_001138283.1	UDPGT	21..519	CDD:278624	153/525 (29%)
ugt2a6	NP_001138283.1	egt	<254..485	CDD:223071	84/237 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584379
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930