DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and ugt2a4

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001170804.2	Gene:	ugt2a4 / 791613	ZFINID:	ZDB-GENE-080721-23	Length:	533	Species:	Danio rerio

Alignment Length:	541	Identity:	153/541 - (28%)
Similarity:	250/541 - (46%)	Gaps:	79/541 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PGK-SHFDFFRPMFLALAERGHNISMYSYFPLEKPVANYT-----DY-VFQ-GMPLLTDIVDLSN 86
            ||: ||:...|.:..||.:|.|::::  ......|...:|     || ||: .|......|..|:
Zfish    27 PGEYSHWHNMRAIIEALVDRNHSVTV--LVSSSSPTVPHTQKARFDYHVFKVNMDKEEAKVIWSD 89

  Fly    87 FESEWKPLGLPFKVPTYFMLHDWGLRS---------CKVALNSPLITQLLKSPIRYDVILLEHFS 142
            |...|.. ....|:...|::  |.:.|         |:..|.:..:.|:| ....|||:    ||
Zfish    90 FTHLWMK-ETDSKLERGFLI--WRVMSNFRRLAADVCRSLLQNDDLLQML-GESHYDVL----FS 146

  Fly   143 N---DCMAAVAHLLNAP-VIAL---------SSCAIMPWHYKRMGSPFINPIMPMNFLP------ 188
            :   .|...:|..||.| ||:|         ..|..||              .|.:::|
Zfish   147 DPMMPCSDLMAQTLNIPQVISLRLTFAYTFERMCGQMP--------------APPSYVPAVALTD 197

  Fly   189 -YTDEMSLIDRLNNFFHFHTVNTLYNMITQPATDALIAERFGPGLPPIN--EIVKNTSLMLINQH 250
             .||.||.::|:.|...:....|::.:.|....|.|..|..|   .|..  |.:....:.||..:
Zfish   198 HLTDRMSFMERVENMLLYFIHTTVFRLNTMLTVDRLYTEIRG---KPTTMCETMGKADIWLIRTY 259

  Fly   251 YALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSAL 314
            :....|||:.||...||||...|.|||.:.:.:.:..| .:||:..|.|||:.:  |.|.:.:.:
Zfish   260 WDFEYPRPFPPNFKFVGGLHCKPAKPLSKEMEEFVQSSGDHGVVVFSLGSMIKN--LTSERANTI 322

  Fly   315 FQSISQLKEYNFVMRW--KSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAI 377
            ..::.|:.: ..|.|:  |:.|:|    ..|...:||:||.|||.|||.:|||:|||..|..|||
Zfish   323 AAALGQIPQ-KVVWRYSGKTPETL----APNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAI 382

  Fly   378 HCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIILDK-KFAERVRRSSEAF 441
            :.||||:..|.:.||..|...:|.:|..|::|....:|..:...|:.:|:. .:.|.:.|.|...
Zfish   383 YHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSYKESIMRLSRIH 447

  Fly   442 RQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLL-IVALRKLIK 505
            ..:|:.|:..|.:|||.|::..||.|::.:|..::|..|:.:||..|.|.|..|: .:.::....
Zfish   448 HDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAALITFLWVKACCF 512

  Fly   506 IFKTAFCRGKISRDT-KTKTQ 525
            :|:....:.:..|.| |:|.:
Zfish   513 LFRRCVRKTRPERKTQKSKNE 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	144/499 (29%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	132/464 (28%)
ugt2a4	NP_001170804.2	UDPGT	21..520	CDD:278624	149/526 (28%)
ugt2a4	NP_001170804.2	egt	<255..486	CDD:223071	81/237 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.810