DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36F1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	558	Identity:	147/558 - (26%)
Similarity:	252/558 - (45%)	Gaps:	95/558 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AHI-LGLF--------QHPGK--------SHFDFFRPMFLALAERGHNISMYSYFPLEKPVANYT 68
            :|| ||||        .:.||        ||:...:.:.:.|..|||:|::..        .:.:
Zfish     3 SHIHLGLFLLLCVLSRSYAGKLLVVPVEGSHWVNMKVLIVELHSRGHSITVVR--------GSSS 59

  Fly    69 DYVFQGMPLLTDI-VDLSNFESE-------------------WKPLGLPFKVPTYFMLH---DWG 110
            .|:.:..||.|.| ||...|:.:                   |..:.|..:     |:|   :..
Zfish    60 WYIEEQSPLYTSITVDNGVFDDDFMEKFLPHLLKIQRQGKSFWNEMALADE-----MIHFVTETH 119

  Fly   111 LRSCKVAL----NSPLITQLLKSPIRYDVILLE-HFSNDCMAAVAHLLNAPVIALSSCAIMPW-- 168
            .:||.:..    |..|:..|  ....|||:|.: .:.:..:  :||.|..|::     ..:.|
Zfish   120 KQSCNMTAILFENETLMNSL--KDAAYDVVLTDPAYGSGVL--LAHRLGLPLV-----YNVRWTV 175

  Fly   169 ----HYKRMGSPFINPIMPMNFLPYTDEMSLIDRLNNFFHFHTVNTLYNMITQPATDALIAERFG 229
                |:....||.  ..:|::.|..||:|:...|:.|...:..:...|:.........|..:.||
Zfish   176 YGEAHFDIAPSPL--SYVPVSGLQLTDKMTFSQRVMNMMTYIMIRYKYSKNFGSPYQELTQKYFG 238

  Fly   230 PGLPPIN--EIVKNTSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNG 291
            |.   :|  .::::..|.|:...:....|||..|||:.:||.|..|.||||..|.:.:..| .:|
Zfish   239 PN---VNFFSLLQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQCKPAKPLPGDLEEFVQSSGEHG 300

  Fly   292 VIYISWGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPSNL----YTFDWLPQ 352
            ||.:|.|::...  |.|.....:..:.:||.:       |.:......:|:||    ...:||||
Zfish   301 VIMMSLGTVFGQ--LLSELNDEIAAAFAQLPQ-------KVIWRYTGPRPANLGNNTLIVNWLPQ 356

  Fly   353 RDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNH 417
            .|||.|||.:.|::|||..|..|||:.|||::..|...||..|...::.:|...||:|...|...
Zfish   357 NDLLGHPKTKLFVAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAKGTAKIVEFATLDRAV 421

  Fly   418 ITRGLRIIL-DKKFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYN 481
            ....|:.:| :..:.|.::|.|:....:|:.|:..|.:|||.|::..||||:::::..::||.|.
Zfish   422 FLEALKEVLHNPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAPHLRAQSFRMSWIEYQ 486

  Fly   482 SIDVLLFWLGILFLLIVALRKLIKIFKTAFCRGKISRD 519
            ||||:|..:.::.:.::.....:|.|.....|.|:.|:
Zfish   487 SIDVILTLMLMVLVFVLLTVYTMKYFCLCLFRKKVKRE 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	141/524 (27%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	120/464 (26%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	140/537 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584279
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740