DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt36F1 and ugt2a5

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001070111.2	Gene:	ugt2a5 / 767705	ZFINID:	ZDB-GENE-060929-796	Length:	532	Species:	Danio rerio

Alignment Length:	519	Identity:	145/519 - (27%)
Similarity:	237/519 - (45%)	Gaps:	96/519 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PGK-SHFDFFRPMFLALAERGHNISMYSYFPLEKPVANYTD------YVF-------QGMPLLTD 80
            ||: ||:...||:..||.::.|::::  ......|...:|.      :||       :....:.|
Zfish    27 PGEYSHWHNMRPVIEALVDKNHSVTV--LVGSSSPTVPHTQKERFEYHVFKVNMEKEEADAAMRD 89

  Fly    81 IVDL------SNFESE---WKPLG--LPFKVPTYFM-LHDWGLRSCKVALNSPLITQLLKSPIRY 133
            ::.|      :.:|.|   ||.:.  :.|. ..||. |.|.||  .|...:|           .|
Zfish    90 MIHLFTNDTAAKYEGEFVMWKVMSKFVEFG-DVYFRGLFDVGL--LKTLRDS-----------NY 140

  Fly   134 DVILLEHFSNDCMA---AVAHLLNAP-VIALSS---------CAIMPWHYKRMGSPFINPIMPMN 185
            ||:    ||:..|.   .:|..||.| ||::.:         |..||              .|.:
Zfish   141 DVL----FSDPMMPFSDLMAQKLNIPQVISMRATFAYAAERLCGQMP--------------APPS 187

  Fly   186 FLP-------YTDEMSLIDRLNNFFHFHTVNTLYNMITQPATDALIAERFGPGLPPIN--EIVKN 241
            ::|       .||.||.::|:.|...:...:..:.::.....|...:|..|   .|..  |.:..
Zfish   188 YVPAVALTDHLTDRMSFMERVENMLLYIVHSIAFPLVATFTFDGYYSEILG---KPTTMCETMGK 249

  Fly   242 TSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNT 305
            ..:.||..::....|||:.||...||||...|.|||.:.|.:.:..| .:||:..|.|||:.:
Zfish   250 VDICLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKELEEFVQSSGDHGVVVFSLGSMIKN-- 312

  Fly   306 LPSGKRSALFQSISQLKEYNFVMRW--KSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHG 368
            |.|.:.:.:..::.|:.: ..|.|:  |:.|:|    ..|...:||:||.|||.|||.:|||:||
Zfish   313 LTSERANTIAAALGQIPQ-KVVWRYSGKTPETL----APNTKIYDWIPQNDLLGHPKTKAFITHG 372

  Fly   369 GLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIILDK-KFAE 432
            |..|..|||:.||||:..|.:|||..|...:|.:|..|::|.....|..:...|:.:::. .:.|
Zfish   373 GTNGLYEAIYHGVPMVGLPLFGDQPDNLLHIKTKGAAVVLDIHTMGSKDLVDALKAVVNNPSYKE 437

  Fly   433 RVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLL 496
            .:.|.|.....:|:.|:..|.:|||.|::..||.|::.:|..::|..|:.:||..|.|.|..|:
Zfish   438 SIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSITALI 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	141/508 (28%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	129/473 (27%)
ugt2a5	NP_001070111.2	UDPGT	21..519	CDD:278624	145/519 (28%)
ugt2a5	NP_001070111.2	egt	<249..485	CDD:223071	82/242 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584378
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.740