DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt2a1

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	XP_038948318.1	Gene:	Ugt2a1 / 63867	RGDID:	69432	Length:	528	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	145/582 - (24%)
Similarity:	247/582 - (42%)	Gaps:	145/582 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLPLALLAFLLRPK----PNDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMY-------- 55
            :.||||...:|...    |:|.:|.|.:            :.:...|.:|.|::::.
  Rat    10 IFPLALTEIVLSGNVVIWPSDGSHWLNI------------KILLEELVQRNHSVTVLAASETLFI 62

  Fly    56 -----SYFPLEKPVANYT----DYVFQGM----------PLLTDIVDLSNFESEW---KPLGLPF 98
                 ::...|:...:||    |.:.:.|          ||           :.|   |.||..|
  Rat    63 NSSPDAFISFEEIPVSYTRSKIDEMIEHMIALWLDHRPTPL-----------TMWAFYKELGKLF 116

  Fly    99 KVPTYFMLHDWGLRSCK-VALNSPLITQLLKSPIRYDVILLEHFSNDCMAAVAHLLNAPVIALSS 162
              ..::.::.   :.|. |..|:.|:.:|.|.  .:||                |::.||.....
  Rat   117 --AAFYKINK---QICDGVLKNATLMARLQKG--GFDV----------------LISDPVTMCGE 158

  Fly   163 CAIMPWHYKRMGSPFINPI----------------MPMNFLP-----YTDEMSLIDRLNNFFHFH 206
            ...:     ::|.||:..:                .|::::|     .||:|:..:|:.|...:.
  Rat   159 LVAL-----KLGIPFVYTLRFSPAFTVERHCGKIPTPVSYVPAALSELTDQMTFGERVKNTISYS 218

  Fly   207 TV-----------NTLYN-MITQPATDALIAERFGPGLPPINEIVKNTSLMLINQHYALTGPRPY 259
            ..           |:.|: ::.:|.|   :.|..|           ...:.|:..::....||||
  Rat   219 LQDYIFKSYWGEWNSYYSRVLGRPTT---LCETMG-----------KAEIWLMRTYWDFEFPRPY 269

  Fly   260 APNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKE 323
            .||...||||...|.||||:.:.:.:..| .:||:..|.||||.:  |...|.:.:..:::|:.:
  Rat   270 LPNFEFVGGLHCKPAKPLPKEMEEFVQTSGEHGVVVFSLGSMVKN--LTEEKANLIASALAQIPQ 332

  Fly   324 YNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPF 388
               .:.|:....:.....||...|||:||.|||.|||.||||:|||..|..|||:.|:||:..|.
  Rat   333 ---KVLWRYKGKIPATLGSNTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPM 394

  Fly   389 YGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIILDKKF-AERVRRSSEAFRQRPIPPIKLA 452
            :.||..|...:|.:|..|.|:.....|..:...:|.::::.| .|...|.|.....:|:.|:..|
  Rat   395 FADQPDNIAHMKAKGAAVEVNMNTMTSADLLSAVRAVINEPFYKENAMRLSRIHHDQPVKPLDRA 459

  Fly   453 TWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWL-----GILFLLIVALRKLIKIFKT 509
            .:|||.|:::.||.|::..|..::|..|:|:||:.|.|     .||.::...|....||.||
  Rat   460 VFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIGFLLACMASAILLVIKCCLFVFQKIGKT 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	130/533 (24%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	118/488 (24%)
Ugt2a1	XP_038948318.1	UDPGT	22..524	CDD:278624	140/570 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860