DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001034638.1	Gene:	Ugt1a5 / 574523	RGDID:	1583689	Length:	531	Species:	Rattus norvegicus

Alignment Length:	559	Identity:	151/559 - (27%)
Similarity:	252/559 - (45%)	Gaps:	78/559 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LALLAFLLRPKP-NDAAHILGLFQHPGKSHFDFFRPMFLALAERGH-----------NISMYSYF 58
            ||.|..||...| .:...:| :|...| ||:...|.:...|..|||           :|....:|
  Rat    10 LAGLLLLLYALPWAEGGKVL-VFPMEG-SHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFF 72

  Fly    59 PLEKPVANYTDYVF--QGMPLLTDIVDLSNFESEWKPLGLPFK-VPTYFMLHDWGLRSCKVALNS 120
            .|:.....||...|  |.|..:..:.:..|:...:.......| :.|..      ||||...|::
  Rat    73 TLQTYPVPYTRQGFRQQMMRNIKVVFETGNYVKTFLETSEILKNISTVL------LRSCMNLLHN 131

  Fly   121 PLITQLLKSPIRYDVILLEHFSNDCMAAVAHLLNAPVI---ALSSCAIMPWHYKRMGSPFINPIM 182
            ..:.|.|.|. .:|::|.:... .|.|.:|..|..|.:   ....|.|        .|.......
  Rat   132 GSLLQHLNSS-SFDMVLTDPVI-PCGAVLAKYLGIPTVFFLRYIPCGI--------DSEATQCPK 186

  Fly   183 PMNFLP-----YTDEMSLIDRLNNFFH-------FHTVNTLYNMITQPATDALIAERFGPGLPPI 235
            |.:::|     .:|.|:.:.|:.|..:       .|...|.|..:   |::.|..|      ..:
  Rat   187 PSSYIPNLLTMLSDHMTFLQRVKNMLYPLALKYICHFSFTRYESL---ASELLQRE------VSL 242

  Fly   236 NEIVKNTSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGS 299
            .|::.:.|:.|....:....|||..||::.:||:.....|||.|.....::.| .:|::..|.||
  Rat   243 VEVLSHASVWLFRGDFVFDYPRPVMPNMVFIGGINCVIKKPLSQEFEAYVNASGEHGIVVFSLGS 307

  Fly   300 MVNSNTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAF 364
            ||:.  :|..|...:.:::.::.:   .:.|:...:.......|.....||||.|||.|||.|||
  Rat   308 MVSE--IPEKKAMEIAEALGRIPQ---TVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAF 367

  Fly   365 ISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLR-IILDK 428
            |:|.|..|..|.|..||||::.|.:|||..|:..::.||.||.::..:..::.:...|: :|.:|
  Rat   368 ITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNK 432

  Fly   429 KFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGIL 493
            .:.|.:.|.|...:.|||.|:.||.:|:|:|:::.||||::..|..:.|..|:|:||      |.
  Rat   433 SYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDV------IG 491

  Fly   494 FLLIVALRKLIKIFKTAF--CR------GKISRDTKTKT 524
            |||.:.|..:..::|:..  ||      |::.:..|:||
  Rat   492 FLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKT 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	133/498 (27%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	118/453 (26%)
Ugt1a5	NP_001034638.1	UDPGT	26..522	CDD:278624	142/533 (27%)
Ugt1a5	NP_001034638.1	egt	<259..505	CDD:223071	84/256 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343984
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.790