DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	577	Identity:	154/577 - (26%)
Similarity:	259/577 - (44%)	Gaps:	102/577 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLAFLLRPKP---------NDAAHILGLFQHPGK-SHFDFFRPMFLALAERGHNISMYSYFPLEK 62
            ::..||:|.|         ..|.::|.|   ||: ||:...|.:...|..|.|.:::  ......
Zfish     1 MMKCLLKPSPLVLIFIFSFTHAGNVLVL---PGEYSHWQNMRNVVDELLNRNHTVTV--LVCSAS 60

  Fly    63 PVANYT-----DYVFQGMPLLTDIVDLSNFE--SEWKPLGLPFKVPTYF----------MLH--- 107
            |..|:|     .|:...:||....:|.::.|  ..|.....|.::.|..          ::|
Zfish    61 PTINFTQQERFQYLVFEVPLSAQELDGASEELIHIWTQHPSPNRLQTALQIIELLGRVRVMHRAM 125

  Fly   108 -DWGLRSCKVALNSPLITQLLKSPIRYDVILLEHFSND----CMAAVAHLLNAPVIALS------ 161
             |..||      |..||.||  |.:::||:.     ||    |...:|.:|..|:: ||
Zfish   126 CDSMLR------NDALIAQL--SALKFDVLF-----NDPMFMCADLLAEMLGLPLV-LSVRISPG 176

  Fly   162 -----SCAIMPWHYKRMGSPFINPIMPMNFLP-----YTDEMSLIDRLNNFFHFHTVNTLYNMIT 216
                 .|..||              .|.:|:|     .||.|..::|:.|.......:..:.::.
Zfish   177 FCLERMCGQMP--------------APPSFVPITQTVLTDRMCFMERVQNMIANIVFSVSFYIVA 227

  Fly   217 QPATDALIAERFGPGLPPIN--EIVKNTSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQ 279
            ..:.|:...:..|   .|..  |.:....:.||..::....|||:.||...||||...|.|||.:
Zfish   228 WISLDSYYTDVLG---KPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSK 289

  Fly   280 HLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRW--KSLESLEDKQP 341
            .:.:.:..| .:||:..|.|||:.:  |.|.:.:.:..::.|:.: ..|.|:  |:.|:|    .
Zfish   290 EMEEFVQSSGDHGVVVFSLGSMIKN--LTSERANTIAAALGQIPQ-KVVWRYSGKTPETL----A 347

  Fly   342 SNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGV 406
            .|...:||:||.|||.|||.:|||:|||..|..|||:.||||:..|.:.||..|...:|.:|..|
Zfish   348 PNTKIYDWIPQNDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAV 412

  Fly   407 IVDFRDFDSNHITRGLRIILDK-KFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQS 470
            ::|....:|..:...|:.:|:. .:.|.:.|.|.....:|:.|:..|.:|||.|::..||.|::.
Zfish   413 VLDINTLESKDLVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRV 477

  Fly   471 EARHINWIVYNSIDVLLFWLGILFLL-IVALRKLIKIFKTAFCRGKISRDT-KTKTQ 525
            :|..::|..|:.:||..|.|.|..|: .:.::....:|:....:.:..|.| |:|.:
Zfish   478 QAHELSWYQYHCLDVAAFLLSIAALITFLWVKACCFLFRRCVRKTRPERKTQKSKNE 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	141/515 (27%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	126/469 (27%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	145/540 (27%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	81/237 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.810