DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and UGT1A1

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_000454.1	Gene:	UGT1A1 / 54658	HGNCID:	12530	Length:	533	Species:	Homo sapiens

Alignment Length:	555	Identity:	158/555 - (28%)
Similarity:	254/555 - (45%)	Gaps:	67/555 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPLALLAFLLRPKPNDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNI-------SMY----SY 57
            |.|.||..:|.|..:.|..|| |....| ||:.........|.:|||.|       |:|    ::
Human    11 LVLGLLLCVLGPVVSHAGKIL-LIPVDG-SHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAF 73

  Fly    58 FPLEK-PVANYTDYVFQGMPLLTDIVDLSN--FESEWKPLGLPFKVPTY-------FMLHDWGLR 112
            :.|:. ||.      ||...:....|.|.:  ||::   ..|...:.||       .||    |.
Human    74 YTLKTYPVP------FQREDVKESFVSLGHNVFEND---SFLQRVIKTYKKIKKDSAML----LS 125

  Fly   113 SCKVAL-NSPLITQLLKSPIRYDVILLEHFSNDCMAAVAHLLNAPVIALSSCAIMPWHYKRMGSP 176
            .|...| |..|:..|.:|  .:||:|.:.|. .|...||..|:.|.:...........::....|
Human   126 GCSHLLHNKELMASLAES--SFDVMLTDPFL-PCSPIVAQYLSLPTVFFLHALPCSLEFEATQCP 187

  Fly   177 FINPI--MPMNFLPYTDEMSLIDRLNNFFHFHTVNTLYNMITQPATDALIAERFGPGLPPINEIV 239
              ||.  :|.....::|.|:.:.|:.|.....:.|.|.:::..|.  |.:|..|......:.:::
Human   188 --NPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPY--ATLASEFLQREVTVQDLL 248

  Fly   240 KNTSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNS 303
            .:.|:.|....:....|||..||::.|||:......||.|.....::.| .:|::..|.||||:.
Human   249 SSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSE 313

  Fly   304 NTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHG 368
              :|..|..|:..::.::.:   .:.|:...:......:|.....||||.|||.||..||||:|.
Human   314 --IPEKKAMAIADALGKIPQ---TVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHA 373

  Fly   369 GLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLR-IILDKKFAE 432
            |..|..|:|..||||::.|.:|||..|:..::.:|.||.::..:..|..:...|: :|.||.:.|
Human   374 GSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKE 438

  Fly   433 RVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLLI 497
            .:.|.|...:.||:.|:.||.:|:|.|:::.||||::..|..:.|..|:|:||      |.|||.
Human   439 NIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV------IGFLLA 497

  Fly   498 VALRKLIKIFKTAF-----C---RGKISRDTKTKT 524
            |.|......||...     |   :|::.:..|:||
Human   498 VVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKT 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	139/493 (28%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	122/448 (27%)
UGT1A1	NP_000454.1	UDPGT	28..524	CDD:278624	148/528 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150110
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.740