Protein Alignment Ugt36F1 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_609909.1
• Gene: Ugt36F1 / 35137
• FlyBaseID: FBgn0027074
• Length: 525
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 541
• Identity: 144/541 - (26%)
• Similarity: 245/541 - (45%)
• Gaps: 76/541 - (14%)

  Fly    27 FQHPGK--------SHFDFFRPMFLALAERGHNISMYS---YFPLEKPVANYTDYVFQGMPLLTD 80
            |...||        ||:...:.:...|..|||.:.:..   .:.||:.: |.|...:.....|.|
Human    22 FAEAGKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSL-NCTVKTYSTSYTLED 85

  Fly    81 IVDLSNFE------SEWKP-----LGLPFKVPTYFMLHDWGLRSCKVALNSPLITQLLKSPIRYD 134
                .|.|      ::||.     ..|.....:.|:  |.....|:...|...:.:.||.. .:|
Human    86 ----QNREFMVFAHAQWKAQAQSIFSLLMSSSSGFL--DLFFSHCRSLFNDRKLVEYLKES-SFD 143

  Fly   135 VILLEHFSNDCMAAVAHLLNAPVIALSS---CAIMPWHYKRMGSPFINPI--MPMNFLPYTDEMS 194
            .:.|:.| :.|...||...:.|.:..:.   |     |:...|:....|:  :|.:.|.::|.|:
Human   144 AVFLDPF-DTCGLIVAKYFSLPSVVFTRGIFC-----HHLEEGAQCPAPLSYVPNDLLGFSDAMT 202

  Fly   195 LIDRL-NNFFHFHT---VNTLYNMITQPATDALIAERFGPGLPPIN--EIVKNTSLMLINQHYAL 253
            ..:|: |:..|...   ...|:....:.|::.|        ..|:.  ::..:||:.|:...:.|
Human   203 FKERVWNHIVHLEDHLFCQYLFRNALEIASEIL--------QTPVTAYDLYSHTSIWLLRTDFVL 259

  Fly   254 TGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQS 317
            ..|:|..||:|.:||:.....||||......::.| .:|::..|.||||:.  :|..|..|:..:
Human   260 DYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSE--IPEKKAMAIADA 322

  Fly   318 ISQLKEYNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVP 382
            :.::.:   .:.|:...:......:|.....||||.|||.||..||||:|.|..|..|:|..|||
Human   323 LGKIPQ---TVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVP 384

  Fly   383 MLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLR-IILDKKFAERVRRSSEAFRQRPI 446
            |::.|.:|||..|:..::.:|.||.::..:..|..:...|: :|.||.:.|.:.|.|...:.||:
Human   385 MVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPV 449

  Fly   447 PPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLLIVALRKLIKIFKTAF 511
            .|:.||.:|:|.|:::.||||::..|..:.|..|:|:||      |.|||.|.|......||...
Human   450 EPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDV------IGFLLAVVLTVAFITFKCCA 508

  Fly   512 -----C---RGKISRDTKTKT 524
                 |   :|::.:..|:||
Human   509 YGYRKCLGKKGRVKKAHKSKT 529

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	GT1_Gtf-like	21..448	CDD:340817	115/455 (25%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	140/527 (27%)