DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt37B1

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_525008.2	Gene:	Ugt37B1 / 53584	FlyBaseID:	FBgn0026755	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	560	Identity:	170/560 - (30%)
Similarity:	266/560 - (47%)	Gaps:	105/560 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEKPVANYTDYVFQGMPLLTDIV--- 82
            |:|||||.....||......|...|||||||:::.:   :.||.:.:.|.....:|:..||:
  Fly    22 ANILGLFTSLSPSHLVIQMSMARILAERGHNVTVVT---ILKPPSLHKDINHILVPMEEDILQAF 83

  Fly    83 ----------DLSN-----FESEWKPLGLPFKVPTYFMLHDWGLRSCKVALNSPLITQLLKSP-I 131
                      |.||     |.|. :.|.     .|:..:.|        .:..||:..|.:.| .
  Fly    84 NSVVGGMTKTDNSNAYVSMFRSV-RQLS-----ETFSKMGD--------VMKQPLVKDLYEHPDN 134

  Fly   132 RYDVILLEHFSNDCMAAVAHLLNAP-VIALSSCAIMPWHYKRMGSPFINPIMPMNFLPY----TD 191
            ::|::::.:|.|....|:||.|..| |:|||:                    |.:||.|    ..
  Fly   135 KFDLVMVGYFMNCYQLALAHKLKVPLVVALSN--------------------PPSFLGYLLGNPW 179

  Fly   192 EMSLIDRLN---------NFFHFHTVNTLYNM-------ITQPATDALIAERFG--PGLPPINEI 238
            |:|.:..::         .|.| ..:|.|.:|       |.:.....:..|.:|  |.||...::
  Fly   180 EVSYVPGMSVSIKGGKPLGFGH-RVLNLLGSMAQRLFMFIIELRNARIYREIYGDDPTLPSYEDL 243

  Fly   239 VKNTSLMLINQHYALTGP-RPYAPNVIEVGGLQVGPIKP--LPQHLLDLLDRSPNGVIYISWGSM 300
            .||.||:....|....|| ||..|.|||:||:||.. :|  |||::...|..:|||.|.:|.||.
  Fly   244 HKNISLIFFASHGISEGPIRPNVPAVIEIGGIQVKE-QPERLPQNMEQFLSEAPNGAILLSLGSN 307

  Fly   301 VNSNTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFI 365
            :..:.|.|.....:|..:|:|:: ..:.:|..|:::..:..:.||: .|:||.|:|.||.|..||
  Fly   308 LKEDHLKSSTVQKMFNVLSKLQQ-KVIWKWDDLDNIPGESENILYS-KWVPQVDVLAHPNITLFI 370

  Fly   366 SHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIILDK-K 429
            :|.|..|.|||.:.|.|||..|.:|||..|:..:...|||:.......:.:...:|:|.:||. |
  Fly   371 THAGKGGLTEAQYHGKPMLALPVFGDQPSNADVMVMHGFGIKQSILTLEEDSFLQGIREVLDNPK 435

  Fly   430 FAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLG--- 491
            :|..|:..|..:|.||:.|.:...:|:|:||:|.|||||||...|:::|..|::||....||
  Fly   436 YATAVKSFSTLYRDRPLSPRETLIYWVEYVIRYHGAPHIQSPVVHMSYIAANNLDVYAVILGTIV 500

  Fly   492 -------ILFLLIVA-LRKLIKIFKTAFCRGKISRDTKTK 523
                   :||.|:|. |||..:       :.|:::..|.|
  Fly   501 ALCFITKLLFGLVVGKLRKNSR-------KAKVNQKHKLK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	158/511 (31%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	136/468 (29%)
Ugt37B1	NP_525008.2	UDPGT	12..523	CDD:278624	167/548 (30%)
Ugt37B1	NP_525008.2	egt	13..483	CDD:223071	154/501 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454658
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940