DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	554	Identity:	160/554 - (28%)
Similarity:	267/554 - (48%)	Gaps:	73/554 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LLPLALLAFLLRPKPNDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEKPVANY 67
            ||.|.::|      ....|:|||||.....||......:..||.:.|||:::.|   :.||...:
  Fly     9 LLLLGVVA------STQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVS---MLKPKVTH 64

  Fly    68 TDYVFQGMPL-----------LTDIVDLSNFESEWKPLGLPFKVPTYFMLHDWGLRSCKVALNSP 121
            .|.....:|:           :|::....|           ..|.|.:.|    |.|..|.:|:.
  Fly    65 KDIHLIVVPMKEEQERIMEDQMTEMAGQKN-----------SLVSTMYRL----LTSMDVMINAQ 114

  Fly   122 LITQLLKSP-------IRYDVILLEHFSNDCMAAVAHLLNAPVIALSSCAIMPWHYKRMGSPFIN 179
              .:||..|       .::|:::|.:|.||....|||.|..|||.....|.:|...|..|:|...
  Fly   115 --AELLSDPRFQRIYETKFDLMILGYFINDFQLGVAHKLKVPVIINWMSAPVPAIDKYTGNPSEL 177

  Fly   180 PIMPMNFLPYTDEMSLIDRLNN-----FFHF------HTVNTLYNMITQPATDALIAERFGPGLP 233
            ..:|:.....|..|..:.|..|     .|.|      :.:..:||.:. |..|          :|
  Fly   178 SYVPLMGTVATQPMGFLKRTENALKSLLFEFIFVVFDYKLTRIYNDVF-PEQD----------MP 231

  Fly   234 PINEIVKNTSLMLINQHYALTGP-RPYAPNVIEVGGLQV-GPIKPLPQHLLDLLDRSPNGVIYIS 296
            .:.|:.||.|:..:..|....|| ||..|.:||:||:|| ....|||:.:...:..:..|.:::|
  Fly   232 TLKELRKNISMAFVGSHLISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNAKQGAVFLS 296

  Fly   297 WGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKI 361
            .||.|.|:|:.......:|:.:|:||| |.:.:|:.||:......:.||. :||||.|:|.||..
  Fly   297 LGSNVKSSTVRPEIVQIIFKVLSELKE-NVIWKWEDLENTPGNSSNILYK-NWLPQDDILAHPNT 359

  Fly   362 RAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIIL 426
            :.||:|.|..|.|||.:.||||:..|.:|||..|:..:::.|:|:.:|......:.:...|:.:|
  Fly   360 KLFITHAGKGGITEAQYHGVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVL 424

  Fly   427 D-KKFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWL 490
            : :|:.:.:.:.|..:|.||:...:...:|.|:::::.|||::||.:.|:|:|..|::|:....:
  Fly   425 ENQKYKQAIGQFSTLYRDRPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIYALIV 489

  Fly   491 GILFLLIVALRKLIKIFKTAF-CRGKISRDTKTK 523
            .||.|.::..|.:.||....| .:.|||: ||.|
  Fly   490 TILVLFVLLTRLVAKIVWNKFGGKAKISQ-TKKK 522

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	143/499 (29%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	125/454 (28%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	140/496 (28%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	144/514 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454652
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.840