DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt35E2

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_652623.2	Gene:	Ugt35E2 / 53506	FlyBaseID:	FBgn0040255	Length:	527	Species:	Drosophila melanogaster

Alignment Length:	545	Identity:	170/545 - (31%)
Similarity:	285/545 - (52%)	Gaps:	48/545 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLLPLALLAFLLRPKPNDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEKPVA 65
            |.:|.|.:|...|.|...:.|.|||:|..|..||:....|....||..||.|:..|.|||::|||
  Fly     5 MLVLRLIVLVVALLPVLLEGARILGVFPIPSHSHYYHALPYLKKLASLGHEITSVSPFPLKEPVA 69

  Fly    66 NYTDYVFQGMPLLTDIVD-----LSNFESEWKPLGLPFKVPTYFMLHDWGLRSCKVALNSPLITQ 125
            |..|.   .:|.|.|.::     |:|.:..|...       .|...:..||.. ||..|..:..:
  Fly    70 NIHDI---PVPELFDNIEEIVGNLTNRKGTWNEF-------EYINQYTLGLVE-KVLENDGVRRE 123

  Fly   126 LLK-SPIRYDVILLEHFSNDCMAAVAHLLNAPVIALSSCAIMPWHYKRMGSPFINPIMPMNFLP- 188
            :|: ..:::|:|:::.:..|.:..:|...:||:|.::|.. ..|....:    :..:.|:.:|.
  Fly   124 ILQPESLQFDLIIVDLWRLDALYGLAAYFDAPIIGIASYG-TDWKIDEL----VGNVSPLAYLQS 183

  Fly   189 ----YTDEMSLIDRLNNFFHFHTVNTLYNMITQPATDALIAERFGPGLP---PINEIVKNTSLML 246
                :.|..:...||.:|.........::...:...:|:..:.| |.:.   .::||.:|.:|:|
  Fly   184 PSFNWFDLDTYGGRLGHFVDQSMAWINWHWRHEERHEAVYRKYF-PKIADKRSLSEITRNFALIL 247

  Fly   247 INQHYALTGPRPYAPNVIEVGGLQVG--PIKPLPQHLLDLLD-RSPNGVIYISWGSMVNSNTLPS 308
            :|||:.:..||||.||:|||||:.|.  | |.|||.|.|.:. ...:||||.|.|:.|.|..|..
  Fly   248 VNQHFTMAPPRPYVPNIIEVGGMHVDQQP-KALPQDLEDFIQGAGEHGVIYFSLGTNVRSRNLSK 311

  Fly   309 GKRSALFQSISQLKEYNFVMRWK-SLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLG 372
            .:|..|..:.:.|.:.   :.|| ..:.|.| .|||:....|.||:|:|.||.::.||:||||..
  Fly   312 DRRKILIDTFASLPQR---ILWKFDADELSD-VPSNVLISPWFPQQDILAHPNVKLFITHGGLQS 372

  Fly   373 TTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGL-RIILDKKFAERVRR 436
            |.|.||.|||||..||:.|||.|...:|.:|.|:::::||..|:.....: :::.:|.|..:.:|
  Fly   373 TVECIHRGVPMLGLPFFYDQFRNMEHIKAQGIGLVLNYRDMTSDEFKDTIHQLLTEKSFGVKAKR 437

  Fly   437 SSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDV-----LLFWLGILFLL 496
            :::.:|.:|:.|:..|.||..:|:::.||||::...|::::|.|:|:||     |..|..:..::
  Fly   438 TADRYRDQPMNPLDTAIWWTHYVLRHKGAPHMRVAGRNLDFITYHSLDVLGTFLLAVWAILSIVV 502

  Fly   497 IVALRKLIKIFKTAFCRGKISRDTK 521
            :.|::.|..|.|:.  :|.||...|
  Fly   503 LCAIKLLRAILKSK--KGNISPKQK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	154/491 (31%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	136/441 (31%)
Ugt35E2	NP_652623.2	egt	23..481	CDD:223071	150/479 (31%)
Ugt35E2	NP_652623.2	YjiC	26..440	CDD:224732	136/435 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454638
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890