DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt35D1

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	550	Identity:	163/550 - (29%)
Similarity:	276/550 - (50%)	Gaps:	80/550 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 PLALLAFLLRPKPNDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEKPVANYTD 69
            |:.||..|| |..::.|.||.:|..|..||:.|..|...:||..||.|:..|.:|..:|..|..|
  Fly     3 PIFLLVCLL-PGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHD 66

  Fly    70 Y----VFQGMPLLTDIVDLSNFESEWKPLGLPFKVPTYFMLHDWGLRSCKVALNSPLITQLLKSP 130
            .    ||:....:..|.  |...|.|:         :...::::.|...|..||:..:.:.:..|
  Fly    67 IPVPEVFENFNEVLRIA--STPRSTWQ---------SSDFINEYVLNLTKTVLNNEGVRRDILGP 120

  Fly   131 IR--YDVILLEHFSNDCMAAVAHLLNAPVIALSSCAIMPWHY-KRMGSPFINPIMPMNFL----- 187
            .:  :|:::::.:..|.::.:|...:||:|.::|.. ..|.. :.||:     :.|:::|
  Fly   121 QKPHFDLVIMDLWRMDVLSGLAAYFDAPIIGMASYG-TDWKIDELMGN-----VSPISYLQSPSS 179

  Fly   188 ------PYTDE-MSLIDRLNNFF-----HFHTVNTLYNMITQPATDALIAERFGPGLPPINEIVK 240
                  .|.:. :.|::|..::.     |.....|||:... |:    :|||     .|::||.:
  Fly   180 RFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFF-PS----VAER-----KPLSEISR 234

  Fly   241 NTSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLD---------RSPNGVIYIS 296
            |..|:|:|||:.|..||||.||:|:||||.|       .|..:.|.         ...:||||.|
  Fly   235 NFDLVLVNQHFTLGPPRPYVPNMIQVGGLHV-------DHSTEALSAELDHFIQGAGESGVIYFS 292

  Fly   297 WGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKI 361
            .|:.|.|.:|...:|..|.::.:.|.:.   :.||..:.|...:|.|::...|.||:.:|.||.:
  Fly   293 LGTNVKSKSLSEDRRKVLLETFASLPQR---IVWKFEDELLPGKPPNVFISKWFPQQAILAHPNV 354

  Fly   362 RAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHI-TRGLRII 425
            :.||:|||||.|.|:||.|.|||..|...|||.|...|:|.|.|::::.:...|... :..:|::
  Fly   355 KLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLL 419

  Fly   426 LDKKFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVL---- 486
            .:|.|.|..|.::..:|.:|:.|::.|.||.|:|:.:.||.|:|...:.:.::.|:|:||.
  Fly   420 TNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFL 484

  Fly   487 ---LFWLGIL-FLLIVALRKLIKIFKTAFC 512
               |..|||: :||::.|||.:.:.|...|
  Fly   485 VGALVILGIVTYLLVMTLRKCLFLIKRGKC 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	146/508 (29%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	130/456 (29%)
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	146/496 (29%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	150/517 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454640
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890