DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt37A2

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	526	Identity:	157/526 - (29%)
Similarity:	256/526 - (48%)	Gaps:	55/526 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 AHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEKPVANYTDYVFQGMPL-------L 78
            |:|||:|.....||..........|||||||:::.:..   |||.|:.:.....:||       :
  Fly    24 ANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVL---KPVVNHKNITVIMVPLTKEESQQM 85

  Fly    79 TDIV------DLSN-FESEWKPLGLPFKVPTYFMLHDWGLRSCKVALNSPLITQL-LKSPIRYDV 135
            :|.:      |.|| ..|..:.:|     ...||..     ....||....:..| |....::|:
  Fly    86 SDTIGAMSKTDNSNMILSMLRMMG-----QMEFMFD-----KMAGALKDDRVRDLYLNRDNKFDL 140

  Fly   136 ILLEHFSNDCMAAVAHLLNAPVIALSSCAIMPWHYKRMGSPFINPIMPMNFLPYTDE-------M 193
            :|..:|.|......|..:.||||.:   |.||  ..::.:|.|...:.:.::|...:       |
  Fly   141 VLSGYFMNVYQLGFAKKVKAPVIVV---ATMP--PNQLLNPLIGNPLEIAYVPSISDSVEKGKGM 200

  Fly   194 SLIDRLNNF---FHFHTVNTLYNMITQPATDALIAERFG--PGLPPINEIVKNTSLMLINQHYAL 253
            |...||..:   |.|    .:::.:||..:..|..|.||  |.:|..:|:||||||:....|...
  Fly   201 SFRQRLAGYSSSFFF----GIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIFFASHAPS 261

  Fly   254 TGP-RPYAPNVIEVGGLQVGPI-KPLPQHLLDLLDRSPNGVIYISWGSMVNSNTLPSGKRSALFQ 316
            .|| ||..|..||:||:||... .||||::.:.|..:.:|.|.:|.||.|..:.:.......:|.
  Fly   262 EGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFLGNATDGAILLSLGSNVKGSHINPDTVVKMFN 326

  Fly   317 SISQLKEYNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGV 381
            .:|:||: ..:.:|:.||....|. .|::...||||.|:|.||.|:.||:|.|..|.|||.:.|.
  Fly   327 VLSKLKQ-RVIWKWEDLEKTPGKS-DNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQYHGK 389

  Fly   382 PMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRG-LRIILDKKFAERVRRSSEAFRQRP 445
            |||..|.:|||..|:..:.::|||:.......:....... |.|:.:.::.::|...|..:|.||
  Fly   390 PMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLYRDRP 454

  Fly   446 IPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLLIVALRKLIK-IFKT 509
            :...:...:|.|:||::.||.|:||...|:::|..|:||:......:|.:|::.|:.|:: |::.
  Fly   455 MSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAVVLVILVLLLKLLLQFIYRK 519

  Fly   510 AFCRGK 515
            .|.:.|
  Fly   520 IFAKPK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	150/495 (30%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	132/452 (29%)
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	147/489 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454655
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	7	6.940