DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	154/529 - (29%)
Similarity:	273/529 - (51%)	Gaps:	45/529 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 AAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEKPVANYTDYVFQGMPLLTDIV-- 82
            ::.||.:|..||:|.:.|.......||.||||:::.:.|..:|   |..::...|...:.:|:
  Fly    31 SSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDK---NEPNFRVIGAKKIHEIMAA 92

  Fly    83 ----DLSNFESEWKPLGLPFKVPTYFMLHDWGLRSCKVALNSPLITQLLKSPIRYDVILLEHFSN 143
                |.:...|:|:.|    .:.|.|:    .|.:..: |:...:..||.|..::|::::|....
  Fly    93 FGNADYTQTASQWQML----TMTTQFL----NLLTTSI-LDDAAVKDLLNSGEKFDLVIMEAVQT 148

  Fly   144 DCMAAVAHLLNAPVIALSSCAIMPWHYKRMGSPFINPIMPMNFLPY-----TDEMSLIDRLNNFF 203
            :.:..:.....|..|.:||........:.||:     |.|:::.|.     |::|...||:.|.|
  Fly   149 EALFGLIQHFGAETIGISSYGTDTHIDELMGN-----ISPLSYNPLLLSSRTEQMDFKDRVMNVF 208

  Fly   204 HFHTVNTLYNMITQPATDALIAERFGPGLPPINEIVKNTSLMLINQHYALTGPRPYAPNVIEVGG 268
            ....:.....::..|:...|.|:.|......::|::.:.:|||:.||::|:.||||.||:|||||
  Fly   209 EASVMWLHKRIVHLPSQRDLYAKYFPTARKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGG 273

  Fly   269 L---QVGPIKPLPQHLLDLLDRSPNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRW 330
            |   |...::||.:.|.:.:::|..||||.|.||.:.|..||...|..|.|:.:.:.:.   :.|
  Fly   274 LHLQQKRKVQPLAKELSEFVEQSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQR---VLW 335

  Fly   331 KSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLN 395
            |..:....::|.|::...|.||.|:|.||.::.||:|||||.|.|:|:.|.|:|..|.:.||.||
  Fly   336 KFEDDQLPEKPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLN 400

  Fly   396 SGAVKQRGFGVIVDFRDFDSNHITRGLRIIL-DKKFAERVRRSSEAFRQRPIPPIKLATWWIEHV 459
            ....||.|:|:..|....::..:|..::.:| :..:|...:..|:.||.:....::.|.||.|:|
  Fly   401 VQRAKQVGYGLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYV 465

  Fly   460 IKYGGAPHIQSEARHINWIVYNSIDV--LLFWLGILFLLIVALRKLIKIFKTAFCR--GKISRD- 519
            :::.||.|::..:|.:::|.::.:|.  ||..:..:.||||.:  |||..:..|..  .||.::
  Fly   466 LRHKGAKHLRCASRDLDFIQFHGLDTWGLLIAITFVSLLIVVI--LIKCLQRVFVSLISKIRKNR 528

  Fly   520 ---TKTKTQ 525
               :|.|||
  Fly   529 AEASKLKTQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	138/483 (29%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	125/437 (29%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	134/462 (29%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	143/492 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454642
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.890