DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	145/524 - (27%)
Similarity:	252/524 - (48%)	Gaps:	61/524 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHFDFFRPMFLALAERGH-----------NISMYSYFPLEKPVANYTDYVFQGMPLLTDIVDLSN 86
            ||:...|.:...|..|||           :|....:|.|:.....||...::...|    ..|.|
  Rat    36 SHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTLQTYPVPYTKEEYRHHLL----GHLQN 96

  Fly    87 -FESEW------KPLGLPFKVPTYFMLHDWGLRSCKVALNSPLITQLLKSPIRYDVILLEHFSND 144
             ||:|:      :.:.....|.|::      :|||:..|::..:.|.|.|. .:||:|.:.|. .
  Rat    97 FFETEFSLKLVLQRMAAVNNVSTFY------VRSCRGLLHNTALIQSLNSS-SFDVVLTDPFF-P 153

  Fly   145 CMAAVAHLLNAPVIALSSCAIMPWHYKRMGSPFINPIMPMNFLPYTDEMSLIDRLNNFFH----F 205
            |.|.:|..|..|.:......:....::...||..:..:|......:|.||.:||:.|..:    .
  Rat   154 CGAVLAMYLRVPAVFFLQSMLCELEFEATNSPNPSSYIPRLLTLNSDHMSFLDRVKNMLYPVPWM 218

  Fly   206 HTVNTLYNMITQPATDALIAERFGPGLPPINEIVKNTSLMLINQHYALTGPRPYAPNVIEVGGLQ 270
            :..:..|..:.:.|:|.|..|      ..:.||:::.|:.|:.:.:....|||:.||::.:||:.
  Rat   219 YLCHVNYGSLARLASDLLQRE------VSVVEILRHASVWLLRKDFVFYYPRPFMPNMVFIGGIN 277

  Fly   271 VGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRWKSLE 334
            ....|||.|.....::.| .:|::..|.||||:.  :|..|...:.:::.::.:   .:.|:...
  Rat   278 CANRKPLSQEFEAYVNASGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQ---TVLWRYTG 337

  Fly   335 SLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAV 399
            :.......|.....||||.|||.|||.||||:|.|..|..|.|..||||::.|.:|||..|:..:
  Rat   338 TRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRM 402

  Fly   400 KQRGFGVIVDFRDFDSNHITRGLR-IILDKKFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYG 463
            :.||.||.::..:..::.:...|: :|.:|.:.|.:.|.|...:.|||.|:.||.:|:|:|:::.
  Rat   403 ETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHK 467

  Fly   464 GAPHIQSEARHINWIVYNSIDVLLFWLGILFLLIVALRKLIKIFKTAF--CR------GKISRDT 520
            ||||::..|..:.|..|:|:||      |.|||.:.|..:..::|:..  ||      |::.:..
  Rat   468 GAPHLRPAAHDLTWYQYHSLDV------IGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSH 526

  Fly   521 KTKT 524
            |:||
  Rat   527 KSKT 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	133/477 (28%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	121/446 (27%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	142/514 (28%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	92/293 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860