DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt1a2

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_958826.1	Gene:	Ugt1a2 / 396527	RGDID:	1549741	Length:	533	Species:	Rattus norvegicus

Alignment Length:	533	Identity:	149/533 - (27%)
Similarity:	247/533 - (46%)	Gaps:	79/533 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 SHFDFFRPMFLALAERGHNISMYS-----------YFPLEKPVANYTDYVFQGMPLLTDIVDLSN 86
            ||:...|.:...|..|||...:.:           :|.|:.....||...:|     .:|  |.|
  Rat    38 SHWLSMRDVVRELHARGHQAVVLAPEVTVHMKGEDFFTLQTYAFPYTKEEYQ-----REI--LGN 95

  Fly    87 FESEWKPLGLPFKVPTYF-------MLHDWGLRSCKVAL-NSPLITQLLKSPIRYDVILLEHFSN 143
            .:..::|...   |.|:|       ...|....||...| |..||.||..|  .:||:|.:...
  Rat    96 AKKGFEPQHF---VKTFFETMASIKKFFDLYANSCAALLHNKTLIQQLNSS--SFDVVLTDPVF- 154

  Fly   144 DCMAAVAHLLNAP-VIALSS--CAIMPWHYKRMGSPFINPIMPMNFLP-----YTDEMSLIDRLN 200
            .|.|.:|..|..| |..|.|  |.|   .|:....|     .|.:::|     .:|.|:.:.|:.
  Rat   155 PCGALLAKYLQIPAVFFLRSVPCGI---DYEATQCP-----KPSSYIPNLLTMLSDHMTFLQRVK 211

  Fly   201 NFFHFHTVNTLYNMITQP----ATDALIAERFGPGLPPINEIVKNTSLMLINQHYALTGPRPYAP 261
            |..:..|:..:.::...|    |::.|..|.      .:.|::.:.|:.|....:....|||..|
  Rat   212 NMLYPLTLKYICHLSITPYESLASELLQREM------SLVEVLSHASVWLFRGDFVFDYPRPIMP 270

  Fly   262 NVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKEYN 325
            |::.:||:.....|||.|.....::.| .:|::..|.||||:.  :|..|...:.:::.::.:
  Rat   271 NMVFIGGINCVIKKPLSQEFEAYVNASGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQ-- 331

  Fly   326 FVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPFYG 390
             .:.|:...:.......|.....||||.|||.|||.||||:|.|..|..|.|..||||::.|.:|
  Rat   332 -TVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFG 395

  Fly   391 DQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLR-IILDKKFAERVRRSSEAFRQRPIPPIKLATW 454
            ||..|:..::.||.||.::..:..::.:...|: :|.:|.:.|.:.|.|...:.|||.|:.||.:
  Rat   396 DQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVF 460

  Fly   455 WIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGILFLLIVALRKLIKIFKTAF--CR---- 513
            |:|:|:::.||||::..|..:.|..|:|:||      |.|||.:.|..:..::|:..  ||
  Rat   461 WVEYVMRHKGAPHLRPAAHDLTWYQYHSLDV------IGFLLAIVLTVVFIVYKSCAYGCRKCFG 519

  Fly   514 --GKISRDTKTKT 524
              |::.:..|:||
  Rat   520 GKGRVKKSHKSKT 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	137/486 (28%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	125/455 (27%)
Ugt1a2	NP_958826.1	UDPGT	28..524	CDD:278624	146/523 (28%)
Ugt1a2	NP_958826.1	egt	<261..507	CDD:223071	84/256 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860