DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt301D1

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	546	Identity:	152/546 - (27%)
Similarity:	252/546 - (46%)	Gaps:	82/546 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MKLLPLALLAFLLRPKPNDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEKPVA 65
            |.:..:.||.|      ...:.||.:...|..||:.:.......|..:||:::..:..|.:.|..
  Fly    11 MLIFLIGLLEF------GAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHE 69

  Fly    66 NYTDYVF------------QGMPLLTDIVDLSNFESEWKPLGLPFKVPTYFMLHDWGLRSCKVAL 118
            |.|:.:.            :.:..:..:.|.:|.|..|                ..||.:.:.|.
  Fly    70 NLTEIIISPSFDIPKHFPKENIFSMQFVSDFNNLELWW----------------TIGLMTTEHAF 118

  Fly   119 NSPLITQLLKS-PIRYDVILLEHFSNDCMAAVAHLLNAPVIALSSCA-----------IMPWHYK 171
            ..|.:.:|::| ...||::::|.|.::.........|.||:.:.:..           :.||
  Fly   119 KDPKVKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTPW--- 180

  Fly   172 RMGSPFINPIMPMNFLPYTDEMSLIDRLNNFFHFHTVNTLYNMITQ-----PATDALIAERF--- 228
                    .::|...|.:||.|:...|..|.:     .:||:.:.:     |....| ||::
  Fly   181 --------SLIPHLLLSHTDRMTFGQRAYNAY-----LSLYDAVMRRWVYLPKMQKL-AEKYFQG 231

  Fly   229 ---GPGLPPINEIVKNTSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRSPN 290
               || ||.:.::.:|.||:|||.|.::..|||..|.:|:|||..:...|.||..|.:.||.:..
  Fly   232 SIEGP-LPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNATY 295

  Fly   291 GVIYISWGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRWK-SLESLEDKQPSNLYTFDWLPQRD 354
            ||||.|.||.|.|..||..|.:.:.::..|||:.   :.|| ..:|:.| .|||:....|:||.|
  Fly   296 GVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQ---VIWKFENDSIGD-LPSNVMIKKWMPQND 356

  Fly   355 LLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHIT 419
            :|.||.::.||:|||:.||.|.|:.|||||..|.||||..|:....:.|:...:.|....::.:.
  Fly   357 ILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLV 421

  Fly   420 RGLR-IILDKKFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSI 483
            |.:. :|.|.::.......|:.||..||.|:..||:|||::|::.||.|::|....|....|..:
  Fly   422 RNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLL 486

  Fly   484 DVL-LFWLGILFLLIVALRKLIKIFK 508
            ||| ...||....:.:..|.:.::.|
  Fly   487 DVLGCLLLGAFLAIWLPWRMIRRVHK 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	144/505 (29%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	129/459 (28%)
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	143/514 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	137/483 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.960