DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt1a8

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_787040.2	Gene:	Ugt1a8 / 301595	RGDID:	708474	Length:	530	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	145/576 - (25%)
Similarity:	251/576 - (43%)	Gaps:	111/576 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LPLALLAFL---------LRPKPNDAAHILGLFQHPGKSHFDFFRPMFLA--LAERGHNISMYSY 57
            |||.:..||         |...|.|.:|              :|....:.  |:.|||.:.:  .
  Rat    10 LPLCVCLFLASGFAQAGRLLVVPMDGSH--------------WFTMQMIVEKLSHRGHEVVV--V 58

  Fly    58 FP-----LEKPVANYTDYVFQGMPLLTDIVDLSNF------ESEWKPLGLPFKVPTYFMLHDWG- 110
            .|     :.|.: |:|...:.....|.|:    |:      .::||..    :|..:.:|...|
  Rat    59 IPEVSWHMGKSL-NFTVKTYSVSYTLEDL----NYHFKFFAHNQWKTQ----EVGMFSLLKHSGK 114

  Fly   111 ------LRSCKVALNSPLITQLLKSPIRYDVILLEHFSNDCMAAVAHLLNAPVIALSS---CAIM 166
                  ...|:.......:.:.||.. .:|.:.|:.| :.|...:|...:.|.:..|.   |
  Rat   115 GFFELLFSHCRSLFKDKKLVEYLKQS-SFDAVFLDPF-DVCGLILAKYFSLPSVVFSGGIFC--- 174

  Fly   167 PWHYKRMGSPFINP--IMPMNFLPYTDEMSLIDRLNNF-----------FHFHTVNTLYNMITQP 218
              ||...|:...:|  .:|.....:||.|:..:|:.|.           :.|.|...:.:.:.|
  Rat   175 --HYLDEGAQCPSPPSYVPRILSKFTDTMTFKERVWNHLSYMKERAFCPYFFKTAVEIASEVLQ- 236

  Fly   219 ATDALIAERFGPGLPPINEIVKNTSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLD 283
             |...:.:.|.|           .|:.:....:.|..|||..||::.:||:.....|||.:....
  Rat   237 -TPVTMRDLFSP-----------VSIWMFRTDFVLEFPRPVMPNMVYIGGINCHQGKPLSKEFEA 289

  Fly   284 LLDRS-PNGVIYISWGSMVNSNTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPSNLYTF 347
            .::.| .:|::..|.||||:.  :|..|...:.:::.::.:   .:.|:...:.......|....
  Rat   290 YVNASGEHGIVVFSLGSMVSE--IPEKKAMEIAEALGRIPQ---TVLWRYTGTRPSNLAKNTILV 349

  Fly   348 DWLPQRDLLCHPKIRAFISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRD 412
            .||||.|||.|||.||||:|.|..|..|.|..||||::.|.:|||..|:..::.||.||.::..:
  Rat   350 KWLPQNDLLGHPKARAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLE 414

  Fly   413 FDSNHITRGLR-IILDKKFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHIN 476
            ..::.:...|: :|.:|.:.|.:.|.|...:.|||.|:.||.:|:|:|:::.||||::..|..:.
  Rat   415 MTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLT 479

  Fly   477 WIVYNSIDVLLFWLGILFLLIVALRKLIKIFKTAF--CR------GKISRDTKTKT 524
            |..|:|:||      |.|||.:.|..:..::|:..  ||      |::.:..|:||
  Rat   480 WYQYHSLDV------IGFLLAIVLTVVFIVYKSCAYGCRKCFGGKGRVKKSHKSKT 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	126/505 (25%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	114/460 (25%)
Ugt1a8	NP_787040.2	UDPGT	26..521	CDD:278624	137/550 (25%)
Ugt1a8	NP_787040.2	egt	<263..504	CDD:223071	82/251 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.860