DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_001129341.1	Gene:	Ugt2a3 / 289533	RGDID:	1308444	Length:	534	Species:	Rattus norvegicus

Alignment Length:	550	Identity:	151/550 - (27%)
Similarity:	242/550 - (44%)	Gaps:	95/550 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 PNDAAHILGLFQHPGKSHFDFFRPMFLALAERGHNISMYSYFPLEKPVANYTDYVFQGMPLLTDI 81
            |.|.:|.|.|            :.:...||.|||.:::..|..:....:..|...|:.:|:|.:.
  Rat    30 PCDMSHWLNL------------KTILEELAARGHEVTVLKYPSIIIDQSKLTPLQFENIPVLYET 82

  Fly    82 VDLSNFESEWKPLGLPFKVPTYFM------LHDWGLR-------SCKVALNSPLITQLLKSPIR- 132
            ....|..:|...|.:.. :|...:      |.|:.|:       .|:    |.|..|.|.:.:|
  Rat    83 EVAENHLNEIVNLAVNV-IPNLSLWEAARTLQDFFLQLTGNFEDLCR----STLYNQTLMNKLRD 142

  Fly   133 --YDVILLEHFSNDCMAAVAHLLNAPVIAL----------SSCAIMPWHYKRMGSPFINPIMPMN 185
              |||::|:... .|...||.:|..|.:..          ..|..:|              :|::
  Rat   143 AKYDVMVLDPVI-PCGELVAEVLQIPFVNTLRFSMGYSMEKYCGQLP--------------VPLS 192

  Fly   186 FLP-----YTDEMSLIDRLNN-----FFHFHTVNTLYNMITQPATDALIAERFGPGLP-PINEIV 239
            ::|     .||.|:..:|:.|     ||.|......:....|..:..|       |.| ...:.|
  Rat   193 YVPVVMGELTDHMTFTERVKNMMLSLFFEFWLQQYDFAFWDQFYSKTL-------GRPTTFCKTV 250

  Fly   240 KNTSLMLINQHYALTGPRPYAPNVIEVGGLQVGPIKPLPQHLLDLLDRS-PNGVIYISWGSMVNS 303
            ....:.||..::.:..||||.||...||||...|.||||:.|.:.:..| .:||:..|.|||:.:
  Rat   251 GKAEIWLIRTYWDIEFPRPYLPNFEFVGGLHCKPAKPLPKELEEFVQSSGEHGVVVFSLGSMIKN 315

  Fly   304 NTLPSGKRSALFQSISQLKEYNFVMRWKSLESLEDKQPS----NLYTFDWLPQRDLLCHPKIRAF 364
              |...|.:.:..:::|:.:       |.|.....|:|:    |....:|:||.|||.|||.|||
  Rat   316 --LTEEKANLIASALAQIPQ-------KVLWRYSGKKPATLGPNTRILNWIPQNDLLGHPKTRAF 371

  Fly   365 ISHGGLLGTTEAIHCGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRGLRIILDK- 428
            |:|||..|..|||:.||||:..|.:|||..|...::.:|..|.|......|..:...||.::::
  Rat   372 ITHGGTNGIYEAIYHGVPMVGIPMFGDQPYNIAHMEAKGAAVKVAINTMTSADLLSALRAVINEP 436

  Fly   429 KFAERVRRSSEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSIDVLLFWLGIL 493
            .:.|...|.|.....:|:.|:..|.:|||.|:::.||.|::..|..::|..|:|:||    :|.|
  Rat   437 SYKENAMRLSRVHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDV----IGFL 497

  Fly   494 FLLIVALRKLIKIFKTAFCRGKISRDTKTK 523
            .:.:|.|..:|.......||....|:.|.|
  Rat   498 LVCVVTLTFVITKCSLFMCRKCCLRERKKK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	140/510 (27%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	127/465 (27%)
Ugt2a3	NP_001129341.1	UDPGT	25..519	CDD:278624	148/540 (27%)
Ugt2a3	NP_001129341.1	egt	<268..506	CDD:223071	88/250 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166343980
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.790