DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt36F1 and Ugt8a

DIOPT Version :9

Sequence 1:	NP_609909.1	Gene:	Ugt36F1 / 35137	FlyBaseID:	FBgn0027074	Length:	525	Species:	Drosophila melanogaster
Sequence 2:	NP_035804.2	Gene:	Ugt8a / 22239	MGIID:	109522	Length:	541	Species:	Mus musculus

Alignment Length:	525	Identity:	128/525 - (24%)
Similarity:	238/525 - (45%)	Gaps:	109/525 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KSHFDFFRPMFLALAERGH----------NISMYSYFPLEK--PVANYTD----------YVFQG 74
            :||...|:.:..||.||||          :|:..:::.|::  .:.|.|.          .:|.|
Mouse    32 ESHLYIFKTLASALHERGHHTVLLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSG 96

  Fly    75 MPLLTDIVDLSNFESEWKPLGLPFKVPTYFMLHDWGLRSCKVALNSPLITQLLKSPIRYDVILLE 139
            .....::||:.                      |...::|.:.:.:..:.|.||.. ::|::|::
Mouse    97 RLTAVELVDIL----------------------DHYTKNCDMMVGNQALIQGLKKE-KFDLLLVD 138

  Fly   140 HFSND-CMAAVAHLLNAPVIALSSCAIMPWHYKRMGSPFINPIMPMNFLP-----YTDEMSLIDR 198
              .|| |...:||||.......|:..   |:...:|:|     .|:.::|     .||.|:.::|
Mouse   139 --PNDMCGFVIAHLLGVKYAVFSTGL---WYPAEVGAP-----APLAYVPEFNSLLTDRMNFLER 193

  Fly   199 LNNFFHFHTVNTLYNMITQPATDALIAERFGPGLPPIN--------EIVKNTSLMLINQHYALTG 255
            :.        ||...:|::.....|:..::...:...|        ::|..:||.::....||..
Mouse   194 MK--------NTGVYLISRIGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEF 250

  Fly   256 PRPYAPNVIEVGGLQVGPIKPLPQHLLDLLD-RSPNGVIYISWGSMVN------SNTLPSGKRSA 313
            |||..|||:.|||:...|..|||:.|...:. ...:|.:.:|:|:.|.      :|.| :|....
Mouse   251 PRPTLPNVVYVGGILTKPASPLPEDLQRWVSGAQEHGFVLVSFGAGVKYLSEDIANKL-AGALGR 314

  Fly   314 LFQSISQLKEYNFVMRWKSLESLEDKQPSNLYTFDWLPQRDLLCHPKIRAFISHGGLLGTTEAIH 378
            |.|.:.          |:...:......:|....:||||.|||.|..||||:|||||....|.::
Mouse   315 LPQKVI----------WRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMY 369

  Fly   379 CGVPMLVTPFYGDQFLNSGAVKQRGFGVIVDFRDFDSNHITRG------LRIILDKKFAERVRRS 437
            .|||::..|.:||.:.....|:.:|.|:::::     |.:|.|      :::|.:..:.:|.::.
Mouse   370 HGVPVVGIPLFGDHYDTMTRVQAKGMGILLEW-----NTVTEGELYDALVKVINNPSYRQRAQKL 429

  Fly   438 SEAFRQRPIPPIKLATWWIEHVIKYGGAPHIQSEARHINWIVYNSID---VLLFWLGILFLLIVA 499
            ||..:.:|..|:...|:||::::::.||.|::|....|::..|..:|   |||....:|:.::..
Mouse   430 SEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFILSY 494

  Fly   500 LRKLI 504
            :.|.|
Mouse   495 VTKFI 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt36F1	NP_609909.1	egt	19..487	CDD:223071	123/506 (24%)
Ugt36F1	NP_609909.1	YjiC	38..461	CDD:224732	113/471 (24%)
Ugt8a	NP_035804.2	UDPGT	21..502	CDD:278624	128/525 (24%)
Ugt8a	NP_035804.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..541
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840194
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.740